COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)

The results of studies of cytokine production in the serum of experimental animals exposed by general vibration and noise of industrial frequency. The aim of the work was comparative research of pro- and anti-inflammatory cytokines in animals under the effect of physical factors. 2 experiments of 4...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S. I. Kurchevenko, G. M. Bodienkova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	vibration noise cytokines experimental animals (rats) Science Q
Acceso en línea:	https://doaj.org/article/9503dd6fcf1641babe627866dc079f6d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9503dd6fcf1641babe627866dc079f6d
record_format	dspace
spelling	oai:doaj.org-article:9503dd6fcf1641babe627866dc079f6d2021-11-23T06:14:28ZCOMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)2541-94202587-9596https://doaj.org/article/9503dd6fcf1641babe627866dc079f6d2013-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1559https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The results of studies of cytokine production in the serum of experimental animals exposed by general vibration and noise of industrial frequency. The aim of the work was comparative research of pro- and anti-inflammatory cytokines in animals under the effect of physical factors. 2 experiments of 4 series of studies within 15, 30, 60 and 120 days were conducted. Intact male albino rats were used as a control group. In all animals serum levels of cytokines IL-1β, IL-10, TNF-a (species-specific diagnostic kits Bender MedSystems (Austria)) were evaluated by ELISA. Mathematical processing of the results was carried out by methods of nonparametric statistics. Experiments on outbred albino rats determined both general patterns and features of the cytokine balance changes depending on the nature of the influence of physical factors in the dynamics of development of disorders in immune system. The decrease of IL-10 level under the influence of vibration is observed in 15 days and the one under the influence of noise is observed in 60 days. The decrease of IL-1β in rats is typical only at the effects of noise in 30 days and doesn't change at the effect of vibration. It was concluded that changes in the contents of cytokines in experimental animals under the effect of general vibration and noise production rate shows different mechanisms basic for the regulation of immune response.S. I. KurchevenkoG. M. BodienkovaScientific Сentre for Family Health and Human Reproduction Problemsarticlevibrationnoisecytokinesexperimental animals (rats)ScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(1), Pp 27-29 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	vibration noise cytokines experimental animals (rats) Science Q
spellingShingle	vibration noise cytokines experimental animals (rats) Science Q S. I. Kurchevenko G. M. Bodienkova COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)
description	The results of studies of cytokine production in the serum of experimental animals exposed by general vibration and noise of industrial frequency. The aim of the work was comparative research of pro- and anti-inflammatory cytokines in animals under the effect of physical factors. 2 experiments of 4 series of studies within 15, 30, 60 and 120 days were conducted. Intact male albino rats were used as a control group. In all animals serum levels of cytokines IL-1β, IL-10, TNF-a (species-specific diagnostic kits Bender MedSystems (Austria)) were evaluated by ELISA. Mathematical processing of the results was carried out by methods of nonparametric statistics. Experiments on outbred albino rats determined both general patterns and features of the cytokine balance changes depending on the nature of the influence of physical factors in the dynamics of development of disorders in immune system. The decrease of IL-10 level under the influence of vibration is observed in 15 days and the one under the influence of noise is observed in 60 days. The decrease of IL-1β in rats is typical only at the effects of noise in 30 days and doesn't change at the effect of vibration. It was concluded that changes in the contents of cytokines in experimental animals under the effect of general vibration and noise production rate shows different mechanisms basic for the regulation of immune response.
format	article
author	S. I. Kurchevenko G. M. Bodienkova
author_facet	S. I. Kurchevenko G. M. Bodienkova
author_sort	S. I. Kurchevenko
title	COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)
title_short	COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)
title_full	COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)
title_fullStr	COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)
title_full_unstemmed	COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)
title_sort	comparative evaluation of cytokine profile in experimental animals under the effect of physical factors (preliminary study)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/9503dd6fcf1641babe627866dc079f6d
work_keys_str_mv	AT sikurchevenko comparativeevaluationofcytokineprofileinexperimentalanimalsundertheeffectofphysicalfactorspreliminarystudy AT gmbodienkova comparativeevaluationofcytokineprofileinexperimentalanimalsundertheeffectofphysicalfactorspreliminarystudy
_version_	1718417147541061632

COMPARATIVE EVALUATION OF CYTOKINE PROFILE IN EXPERIMENTAL ANIMALS UNDER THE EFFECT OF PHYSICAL FACTORS (PRELIMINARY STUDY)

Ejemplares similares