Role of Septins in Endothelial Cells and Platelets

Septins are conserved cytoskeletal GTP-binding proteins identified in almost all eukaryotes except higher plants. Mammalian septins comprise 13 family members with either ubiquitous or organ- and tissue-specific expression patterns. They form filamentous oligomers and complexes with other proteins t...

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Autores principales:	Katharina Neubauer, Barbara Zieger
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	septins platelets endothelial cells angiogenesis cell-cell junction exocytosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9515b3810aa641f5ba66f0f3f4ad87a7
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spelling	oai:doaj.org-article:9515b3810aa641f5ba66f0f3f4ad87a72021-11-11T07:00:27ZRole of Septins in Endothelial Cells and Platelets2296-634X10.3389/fcell.2021.768409https://doaj.org/article/9515b3810aa641f5ba66f0f3f4ad87a72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.768409/fullhttps://doaj.org/toc/2296-634XSeptins are conserved cytoskeletal GTP-binding proteins identified in almost all eukaryotes except higher plants. Mammalian septins comprise 13 family members with either ubiquitous or organ- and tissue-specific expression patterns. They form filamentous oligomers and complexes with other proteins to serve as diffusions barrier and/or multi-molecular scaffolds to function in a physiologically regulated manner. Diverse septins are highly expressed in endothelial cells and platelets, which play an important role in hemostasis, a process to prevent blood loss after vascular injury. Endothelial septins are involved in cellular processes such as exocytosis and in processes concerning organismal level, like angiogenesis. Septins are additionally found in endothelial cell-cell junctions where their presence is required to maintain the integrity of the barrier function of vascular endothelial monolayers. In platelets, septins are important for activation, degranulation, adhesion, and aggregation. They have been identified as mediators of distinct platelet functions and being essential in primary and secondary hemostatic processes. Septin-knockout mouse studies show the relevance of septins in several aspects of hemostasis. This is in line with reports that dysregulation of septins is clinically relevant in human bleeding disorders. The precise function of septins in the biology of endothelial cells and platelets remains poorly understood. The following mini-review highlights the current knowledge about the role of septin cytoskeleton in regulating critical functions in these two cell types.Katharina NeubauerBarbara ZiegerFrontiers Media S.A.articleseptinsplateletsendothelial cellsangiogenesiscell-cell junctionexocytosisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	septins platelets endothelial cells angiogenesis cell-cell junction exocytosis Biology (General) QH301-705.5
spellingShingle	septins platelets endothelial cells angiogenesis cell-cell junction exocytosis Biology (General) QH301-705.5 Katharina Neubauer Barbara Zieger Role of Septins in Endothelial Cells and Platelets
description	Septins are conserved cytoskeletal GTP-binding proteins identified in almost all eukaryotes except higher plants. Mammalian septins comprise 13 family members with either ubiquitous or organ- and tissue-specific expression patterns. They form filamentous oligomers and complexes with other proteins to serve as diffusions barrier and/or multi-molecular scaffolds to function in a physiologically regulated manner. Diverse septins are highly expressed in endothelial cells and platelets, which play an important role in hemostasis, a process to prevent blood loss after vascular injury. Endothelial septins are involved in cellular processes such as exocytosis and in processes concerning organismal level, like angiogenesis. Septins are additionally found in endothelial cell-cell junctions where their presence is required to maintain the integrity of the barrier function of vascular endothelial monolayers. In platelets, septins are important for activation, degranulation, adhesion, and aggregation. They have been identified as mediators of distinct platelet functions and being essential in primary and secondary hemostatic processes. Septin-knockout mouse studies show the relevance of septins in several aspects of hemostasis. This is in line with reports that dysregulation of septins is clinically relevant in human bleeding disorders. The precise function of septins in the biology of endothelial cells and platelets remains poorly understood. The following mini-review highlights the current knowledge about the role of septin cytoskeleton in regulating critical functions in these two cell types.
format	article
author	Katharina Neubauer Barbara Zieger
author_facet	Katharina Neubauer Barbara Zieger
author_sort	Katharina Neubauer
title	Role of Septins in Endothelial Cells and Platelets
title_short	Role of Septins in Endothelial Cells and Platelets
title_full	Role of Septins in Endothelial Cells and Platelets
title_fullStr	Role of Septins in Endothelial Cells and Platelets
title_full_unstemmed	Role of Septins in Endothelial Cells and Platelets
title_sort	role of septins in endothelial cells and platelets
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9515b3810aa641f5ba66f0f3f4ad87a7
work_keys_str_mv	AT katharinaneubauer roleofseptinsinendothelialcellsandplatelets AT barbarazieger roleofseptinsinendothelialcellsandplatelets
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Role of Septins in Endothelial Cells and Platelets

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