Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial

Abstract Background Common mental disorders such as depression and anxiety are major contributors to the global burden of disease. Affected individuals suffer reduced quality of life, impaired functioning and reduced capacity to work. Maintaining employment is an important determinant for health and...

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Autores principales:	Kenneth Sandin, Ragne G. H. Gjengedal, Kåre Osnes, Marit Hannisdal, Torkil Berge, Jonas S. R. Leversen, Lars G. Røv, Silje Endresen Reme, Suzanne Lagerveld, Roland Blonk, Hans M. Nordahl, Gemma Shields, Adrian Wells, Odin Hjemdal
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Sick leave Anxiety Depression Work-focused interventions Metacognitive therapy Cost-effectiveness Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9517dfb1ed7e4595adf76fe176756ab6
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spelling	oai:doaj.org-article:9517dfb1ed7e4595adf76fe176756ab62021-11-28T12:28:37ZMetacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial10.1186/s13063-021-05822-41745-6215https://doaj.org/article/9517dfb1ed7e4595adf76fe176756ab62021-11-01T00:00:00Zhttps://doi.org/10.1186/s13063-021-05822-4https://doaj.org/toc/1745-6215Abstract Background Common mental disorders such as depression and anxiety are major contributors to the global burden of disease. Affected individuals suffer reduced quality of life, impaired functioning and reduced capacity to work. Maintaining employment is an important determinant for health and wellbeing, and the economic impact of depression and anxiety is a significant societal expense. Treatments providing effective symptom reduction and helping patients return to work (RTW) would thus have substantial public health benefits. The present study will explore the effectiveness of metacognitive therapy (MCT) and work-focused interventions on reducing symptoms and increasing RTW rates for patients on sick leave due to depression and anxiety. Methods The study is a randomised controlled wait-list trial (RCT; N = 240). The intervention group will receive protocol-based MCT and work-focused interventions immediately after inclusion. The control condition is a wait-list control group. All patients will receive up to 12 weekly sessions. The study context is a Norwegian outpatient clinic part of a national programme aimed at reducing sick leave. The co-primary outcomes are change in RTW and symptoms of depression and anxiety at the end of treatment. In addition to self-report, sick leave will also be collected from national registries from 2 years prior to intervention to 4 years after intervention. Symptoms of scores will be collected by self-report at pre- and post-treatment and at 6 and 12 months follow-up after treatment. A cost-effectiveness analysis will use total cost and quality-adjusted life-years as the secondary outcomes. Discussion There is broad consensus on the importance of identifying treatment that effectively reduces depression and anxiety symptoms and aids RTW. This study is an important contribution to the field as it is the first RCT on MCT and work-focused interventions for patients on sick leave due to anxiety and depression. Trial registration ClinicalTrials.gov NCT03301922 . Registered on October 4, 2017.Kenneth SandinRagne G. H. GjengedalKåre OsnesMarit HannisdalTorkil BergeJonas S. R. LeversenLars G. RøvSilje Endresen RemeSuzanne LagerveldRoland BlonkHans M. NordahlGemma ShieldsAdrian WellsOdin HjemdalBMCarticleSick leaveAnxietyDepressionWork-focused interventionsMetacognitive therapyCost-effectivenessMedicine (General)R5-920ENTrials, Vol 22, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sick leave Anxiety Depression Work-focused interventions Metacognitive therapy Cost-effectiveness Medicine (General) R5-920
spellingShingle	Sick leave Anxiety Depression Work-focused interventions Metacognitive therapy Cost-effectiveness Medicine (General) R5-920 Kenneth Sandin Ragne G. H. Gjengedal Kåre Osnes Marit Hannisdal Torkil Berge Jonas S. R. Leversen Lars G. Røv Silje Endresen Reme Suzanne Lagerveld Roland Blonk Hans M. Nordahl Gemma Shields Adrian Wells Odin Hjemdal Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial
description	Abstract Background Common mental disorders such as depression and anxiety are major contributors to the global burden of disease. Affected individuals suffer reduced quality of life, impaired functioning and reduced capacity to work. Maintaining employment is an important determinant for health and wellbeing, and the economic impact of depression and anxiety is a significant societal expense. Treatments providing effective symptom reduction and helping patients return to work (RTW) would thus have substantial public health benefits. The present study will explore the effectiveness of metacognitive therapy (MCT) and work-focused interventions on reducing symptoms and increasing RTW rates for patients on sick leave due to depression and anxiety. Methods The study is a randomised controlled wait-list trial (RCT; N = 240). The intervention group will receive protocol-based MCT and work-focused interventions immediately after inclusion. The control condition is a wait-list control group. All patients will receive up to 12 weekly sessions. The study context is a Norwegian outpatient clinic part of a national programme aimed at reducing sick leave. The co-primary outcomes are change in RTW and symptoms of depression and anxiety at the end of treatment. In addition to self-report, sick leave will also be collected from national registries from 2 years prior to intervention to 4 years after intervention. Symptoms of scores will be collected by self-report at pre- and post-treatment and at 6 and 12 months follow-up after treatment. A cost-effectiveness analysis will use total cost and quality-adjusted life-years as the secondary outcomes. Discussion There is broad consensus on the importance of identifying treatment that effectively reduces depression and anxiety symptoms and aids RTW. This study is an important contribution to the field as it is the first RCT on MCT and work-focused interventions for patients on sick leave due to anxiety and depression. Trial registration ClinicalTrials.gov NCT03301922 . Registered on October 4, 2017.
format	article
author	Kenneth Sandin Ragne G. H. Gjengedal Kåre Osnes Marit Hannisdal Torkil Berge Jonas S. R. Leversen Lars G. Røv Silje Endresen Reme Suzanne Lagerveld Roland Blonk Hans M. Nordahl Gemma Shields Adrian Wells Odin Hjemdal
author_facet	Kenneth Sandin Ragne G. H. Gjengedal Kåre Osnes Marit Hannisdal Torkil Berge Jonas S. R. Leversen Lars G. Røv Silje Endresen Reme Suzanne Lagerveld Roland Blonk Hans M. Nordahl Gemma Shields Adrian Wells Odin Hjemdal
author_sort	Kenneth Sandin
title	Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial
title_short	Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial
title_full	Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial
title_fullStr	Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial
title_full_unstemmed	Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial
title_sort	metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9517dfb1ed7e4595adf76fe176756ab6
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Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial

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