Lipid peroxidation as a hallmark of severity in COVID-19 patients

Background: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in response to infections. A defective redox balance has been related to viral pathogenesis developing a massive induction of cell death provoked by oxidative stress. The aim of this study is to per...

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Autores principales:	Marta Martín-Fernández, Rocío Aller, María Heredia-Rodríguez, Esther Gómez-Sánchez, Pedro Martínez-Paz, Hugo Gonzalo-Benito, Laura Sánchez-de Prada, Óscar Gorgojo, Irene Carnicero-Frutos, Eduardo Tamayo, Álvaro Tamayo-Velasco
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Oxidative stress Lipid peroxidation COVID-19 Intubation Mortality Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9518adb7a6d14878835f097ab57f9d15
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spelling	oai:doaj.org-article:9518adb7a6d14878835f097ab57f9d152021-11-12T04:33:10ZLipid peroxidation as a hallmark of severity in COVID-19 patients2213-231710.1016/j.redox.2021.102181https://doaj.org/article/9518adb7a6d14878835f097ab57f9d152021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213231721003414https://doaj.org/toc/2213-2317Background: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in response to infections. A defective redox balance has been related to viral pathogenesis developing a massive induction of cell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profile evaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order to characterize its role in diagnosis and severity of this disease. Methods: Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/death risk was evaluated by multivariable regression analysis. Probability of intubation/death to day-28 was analyzed by using Kaplan-Meier curves and tested with the log-rank test. Results: Antioxidant enzymes (Superoxide dismutase (SOD) and Catalase) and oxidative cell damage (Carbonyl and Lipid peroxidation (LPO)) levels were significantly higher in COVID-19 patients while total antioxidant capacity (ABTS and FRAP) levels were lower in these patients. The comparison of oxidative stress molecules’ levels across COVID-19 severity revealed that only LPO was statistically different between mild and intubated/death COVID-19 patients. COX multivariate regression analysis identified LPO levels over the OOP (LPO>1948.17 μM) as an independent risk factor for 28-day intubation/death in COVID-19 patients [OR: 2.57; 95% CI: 1.10–5.99; p = 0.029]. Furthermore, Kaplan-Meier curve analysis revealed that COVID-19 patients showing LPO levels above 1948.17 μM were intubated or died 8.4 days earlier on average (mean survival time 15.4 vs 23.8 days) when assessing 28-day intubation/death risk (p < 0.001). Conclusion: These findings deepen our knowledge of oxidative stress status in SARS-CoV-2 infection, supporting its important role in COVID-19. In fact, higher lipid peroxidation levels are independently associated to a higher risk of intubation or death at 28 days in COVID-19 patients.Marta Martín-FernándezRocío AllerMaría Heredia-RodríguezEsther Gómez-SánchezPedro Martínez-PazHugo Gonzalo-BenitoLaura Sánchez-de PradaÓscar GorgojoIrene Carnicero-FrutosEduardo TamayoÁlvaro Tamayo-VelascoElsevierarticleOxidative stressLipid peroxidationCOVID-19IntubationMortalityMedicine (General)R5-920Biology (General)QH301-705.5ENRedox Biology, Vol 48, Iss , Pp 102181- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oxidative stress Lipid peroxidation COVID-19 Intubation Mortality Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Oxidative stress Lipid peroxidation COVID-19 Intubation Mortality Medicine (General) R5-920 Biology (General) QH301-705.5 Marta Martín-Fernández Rocío Aller María Heredia-Rodríguez Esther Gómez-Sánchez Pedro Martínez-Paz Hugo Gonzalo-Benito Laura Sánchez-de Prada Óscar Gorgojo Irene Carnicero-Frutos Eduardo Tamayo Álvaro Tamayo-Velasco Lipid peroxidation as a hallmark of severity in COVID-19 patients
description	Background: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in response to infections. A defective redox balance has been related to viral pathogenesis developing a massive induction of cell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profile evaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order to characterize its role in diagnosis and severity of this disease. Methods: Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/death risk was evaluated by multivariable regression analysis. Probability of intubation/death to day-28 was analyzed by using Kaplan-Meier curves and tested with the log-rank test. Results: Antioxidant enzymes (Superoxide dismutase (SOD) and Catalase) and oxidative cell damage (Carbonyl and Lipid peroxidation (LPO)) levels were significantly higher in COVID-19 patients while total antioxidant capacity (ABTS and FRAP) levels were lower in these patients. The comparison of oxidative stress molecules’ levels across COVID-19 severity revealed that only LPO was statistically different between mild and intubated/death COVID-19 patients. COX multivariate regression analysis identified LPO levels over the OOP (LPO>1948.17 μM) as an independent risk factor for 28-day intubation/death in COVID-19 patients [OR: 2.57; 95% CI: 1.10–5.99; p = 0.029]. Furthermore, Kaplan-Meier curve analysis revealed that COVID-19 patients showing LPO levels above 1948.17 μM were intubated or died 8.4 days earlier on average (mean survival time 15.4 vs 23.8 days) when assessing 28-day intubation/death risk (p < 0.001). Conclusion: These findings deepen our knowledge of oxidative stress status in SARS-CoV-2 infection, supporting its important role in COVID-19. In fact, higher lipid peroxidation levels are independently associated to a higher risk of intubation or death at 28 days in COVID-19 patients.
format	article
author	Marta Martín-Fernández Rocío Aller María Heredia-Rodríguez Esther Gómez-Sánchez Pedro Martínez-Paz Hugo Gonzalo-Benito Laura Sánchez-de Prada Óscar Gorgojo Irene Carnicero-Frutos Eduardo Tamayo Álvaro Tamayo-Velasco
author_facet	Marta Martín-Fernández Rocío Aller María Heredia-Rodríguez Esther Gómez-Sánchez Pedro Martínez-Paz Hugo Gonzalo-Benito Laura Sánchez-de Prada Óscar Gorgojo Irene Carnicero-Frutos Eduardo Tamayo Álvaro Tamayo-Velasco
author_sort	Marta Martín-Fernández
title	Lipid peroxidation as a hallmark of severity in COVID-19 patients
title_short	Lipid peroxidation as a hallmark of severity in COVID-19 patients
title_full	Lipid peroxidation as a hallmark of severity in COVID-19 patients
title_fullStr	Lipid peroxidation as a hallmark of severity in COVID-19 patients
title_full_unstemmed	Lipid peroxidation as a hallmark of severity in COVID-19 patients
title_sort	lipid peroxidation as a hallmark of severity in covid-19 patients
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9518adb7a6d14878835f097ab57f9d15
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Lipid peroxidation as a hallmark of severity in COVID-19 patients

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