Modeling medulloblastoma in vivo and with human cerebellar organoids

Group 3 medulloblastoma (MB) is considered one of the most aggressive forms of this cancer. Here, the authors show that Otx2 and c-MYC oncogenes can drive Group 3 MB formation in mouse and human cerebellar organoids while SMARCA4 overexpression or a EZH2-specific inhibitor can inhibit tumorigenesis.

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Autores principales:	Claudio Ballabio, Marica Anderle, Matteo Gianesello, Chiara Lago, Evelina Miele, Marina Cardano, Giuseppe Aiello, Silvano Piazza, Davide Caron, Francesca Gianno, Andrea Ciolfi, Lucia Pedace, Angela Mastronuzzi, Marco Tartaglia, Franco Locatelli, Elisabetta Ferretti, Felice Giangaspero, Luca Tiberi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9519a8f838f84cd89a2a82dbc13a35e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:9519a8f838f84cd89a2a82dbc13a35e42021-12-02T14:41:03ZModeling medulloblastoma in vivo and with human cerebellar organoids10.1038/s41467-019-13989-32041-1723https://doaj.org/article/9519a8f838f84cd89a2a82dbc13a35e42020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13989-3https://doaj.org/toc/2041-1723Group 3 medulloblastoma (MB) is considered one of the most aggressive forms of this cancer. Here, the authors show that Otx2 and c-MYC oncogenes can drive Group 3 MB formation in mouse and human cerebellar organoids while SMARCA4 overexpression or a EZH2-specific inhibitor can inhibit tumorigenesis.Claudio BallabioMarica AnderleMatteo GianeselloChiara LagoEvelina MieleMarina CardanoGiuseppe AielloSilvano PiazzaDavide CaronFrancesca GiannoAndrea CiolfiLucia PedaceAngela MastronuzziMarco TartagliaFranco LocatelliElisabetta FerrettiFelice GiangasperoLuca TiberiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudio Ballabio Marica Anderle Matteo Gianesello Chiara Lago Evelina Miele Marina Cardano Giuseppe Aiello Silvano Piazza Davide Caron Francesca Gianno Andrea Ciolfi Lucia Pedace Angela Mastronuzzi Marco Tartaglia Franco Locatelli Elisabetta Ferretti Felice Giangaspero Luca Tiberi Modeling medulloblastoma in vivo and with human cerebellar organoids
description	Group 3 medulloblastoma (MB) is considered one of the most aggressive forms of this cancer. Here, the authors show that Otx2 and c-MYC oncogenes can drive Group 3 MB formation in mouse and human cerebellar organoids while SMARCA4 overexpression or a EZH2-specific inhibitor can inhibit tumorigenesis.
format	article
author	Claudio Ballabio Marica Anderle Matteo Gianesello Chiara Lago Evelina Miele Marina Cardano Giuseppe Aiello Silvano Piazza Davide Caron Francesca Gianno Andrea Ciolfi Lucia Pedace Angela Mastronuzzi Marco Tartaglia Franco Locatelli Elisabetta Ferretti Felice Giangaspero Luca Tiberi
author_facet	Claudio Ballabio Marica Anderle Matteo Gianesello Chiara Lago Evelina Miele Marina Cardano Giuseppe Aiello Silvano Piazza Davide Caron Francesca Gianno Andrea Ciolfi Lucia Pedace Angela Mastronuzzi Marco Tartaglia Franco Locatelli Elisabetta Ferretti Felice Giangaspero Luca Tiberi
author_sort	Claudio Ballabio
title	Modeling medulloblastoma in vivo and with human cerebellar organoids
title_short	Modeling medulloblastoma in vivo and with human cerebellar organoids
title_full	Modeling medulloblastoma in vivo and with human cerebellar organoids
title_fullStr	Modeling medulloblastoma in vivo and with human cerebellar organoids
title_full_unstemmed	Modeling medulloblastoma in vivo and with human cerebellar organoids
title_sort	modeling medulloblastoma in vivo and with human cerebellar organoids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9519a8f838f84cd89a2a82dbc13a35e4
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Modeling medulloblastoma in vivo and with human cerebellar organoids

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