Modeling medulloblastoma in vivo and with human cerebellar organoids

Modeling medulloblastoma in vivo and with human cerebellar organoids

Group 3 medulloblastoma (MB) is considered one of the most aggressive forms of this cancer. Here, the authors show that Otx2 and c-MYC oncogenes can drive Group 3 MB formation in mouse and human cerebellar organoids while SMARCA4 overexpression or a EZH2-specific inhibitor can inhibit tumorigenesis.

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Auteurs principaux: Claudio Ballabio, Marica Anderle, Matteo Gianesello, Chiara Lago, Evelina Miele, Marina Cardano, Giuseppe Aiello, Silvano Piazza, Davide Caron, Francesca Gianno, Andrea Ciolfi, Lucia Pedace, Angela Mastronuzzi, Marco Tartaglia, Franco Locatelli, Elisabetta Ferretti, Felice Giangaspero, Luca Tiberi
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/9519a8f838f84cd89a2a82dbc13a35e4
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Internet

https://doaj.org/article/9519a8f838f84cd89a2a82dbc13a35e4

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