Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.

Guardado en:
Detalles Bibliográficos
Autores principales: Heng-Huan Lee, Ying-Nai Wang, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Yu-Han Wang, Zhou Jiang, Shouping Xu, Jun Yao, Yufan Qiu, Yi-Hsin Hsu, Wei-Lun Hwang, Meisi Yan, Jong-Ho Cha, Jennifer L. Hsu, Jia Shen, Yuanqing Ye, Xifeng Wu, Ming-Feng Hou, Lin-Ming Tseng, Shao-Chun Wang, Mei-Ren Pan, Chin-Hua Yang, Yuan-Liang Wang, Hirohito Yamaguchi, Da Pang, Gabriel N. Hortobagyi, Dihua Yu, Mien-Chie Hung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/951d591c8f644e74b61e110feda5e096
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:951d591c8f644e74b61e110feda5e096
record_format dspace
spelling oai:doaj.org-article:951d591c8f644e74b61e110feda5e0962021-12-02T15:43:05ZHuman ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation10.1038/s41467-021-23075-22041-1723https://doaj.org/article/951d591c8f644e74b61e110feda5e0962021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23075-2https://doaj.org/toc/2041-1723Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.Heng-Huan LeeYing-Nai WangWen-Hao YangWeiya XiaYongkun WeiLi-Chuan ChanYu-Han WangZhou JiangShouping XuJun YaoYufan QiuYi-Hsin HsuWei-Lun HwangMeisi YanJong-Ho ChaJennifer L. HsuJia ShenYuanqing YeXifeng WuMing-Feng HouLin-Ming TsengShao-Chun WangMei-Ren PanChin-Hua YangYuan-Liang WangHirohito YamaguchiDa PangGabriel N. HortobagyiDihua YuMien-Chie HungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Heng-Huan Lee
Ying-Nai Wang
Wen-Hao Yang
Weiya Xia
Yongkun Wei
Li-Chuan Chan
Yu-Han Wang
Zhou Jiang
Shouping Xu
Jun Yao
Yufan Qiu
Yi-Hsin Hsu
Wei-Lun Hwang
Meisi Yan
Jong-Ho Cha
Jennifer L. Hsu
Jia Shen
Yuanqing Ye
Xifeng Wu
Ming-Feng Hou
Lin-Ming Tseng
Shao-Chun Wang
Mei-Ren Pan
Chin-Hua Yang
Yuan-Liang Wang
Hirohito Yamaguchi
Da Pang
Gabriel N. Hortobagyi
Dihua Yu
Mien-Chie Hung
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
description Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.
format article
author Heng-Huan Lee
Ying-Nai Wang
Wen-Hao Yang
Weiya Xia
Yongkun Wei
Li-Chuan Chan
Yu-Han Wang
Zhou Jiang
Shouping Xu
Jun Yao
Yufan Qiu
Yi-Hsin Hsu
Wei-Lun Hwang
Meisi Yan
Jong-Ho Cha
Jennifer L. Hsu
Jia Shen
Yuanqing Ye
Xifeng Wu
Ming-Feng Hou
Lin-Ming Tseng
Shao-Chun Wang
Mei-Ren Pan
Chin-Hua Yang
Yuan-Liang Wang
Hirohito Yamaguchi
Da Pang
Gabriel N. Hortobagyi
Dihua Yu
Mien-Chie Hung
author_facet Heng-Huan Lee
Ying-Nai Wang
Wen-Hao Yang
Weiya Xia
Yongkun Wei
Li-Chuan Chan
Yu-Han Wang
Zhou Jiang
Shouping Xu
Jun Yao
Yufan Qiu
Yi-Hsin Hsu
Wei-Lun Hwang
Meisi Yan
Jong-Ho Cha
Jennifer L. Hsu
Jia Shen
Yuanqing Ye
Xifeng Wu
Ming-Feng Hou
Lin-Ming Tseng
Shao-Chun Wang
Mei-Ren Pan
Chin-Hua Yang
Yuan-Liang Wang
Hirohito Yamaguchi
Da Pang
Gabriel N. Hortobagyi
Dihua Yu
Mien-Chie Hung
author_sort Heng-Huan Lee
title Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
title_short Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
title_full Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
title_fullStr Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
title_full_unstemmed Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
title_sort human ribonuclease 1 serves as a secretory ligand of ephrin a4 receptor and induces breast tumor initiation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/951d591c8f644e74b61e110feda5e096
work_keys_str_mv AT henghuanlee humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT yingnaiwang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT wenhaoyang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT weiyaxia humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT yongkunwei humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT lichuanchan humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT yuhanwang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT zhoujiang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT shoupingxu humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT junyao humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT yufanqiu humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT yihsinhsu humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT weilunhwang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT meisiyan humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT jonghocha humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT jenniferlhsu humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT jiashen humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT yuanqingye humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT xifengwu humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT mingfenghou humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT linmingtseng humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT shaochunwang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT meirenpan humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT chinhuayang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT yuanliangwang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT hirohitoyamaguchi humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT dapang humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT gabrielnhortobagyi humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT dihuayu humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
AT mienchiehung humanribonuclease1servesasasecretoryligandofephrina4receptorandinducesbreasttumorinitiation
_version_ 1718385822246371328

Ejemplares similares