Cell entry and trafficking of human adenovirus bound to blood factor X is determined by the fiber serotype and not hexon:heparan sulfate interaction.
Human adenovirus serotype 5 (HAdV5)-based vectors administered intravenously accumulate in the liver as the result of their direct binding to blood coagulation factor X (FX) and subsequent interaction of the FX-HAdV5 complex with heparan sulfate proteoglycan (HSPG) at the surface of liver cells. Int...
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| Auteurs principaux: | , , , , , , , |
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| Format: | article |
| Langue: | EN |
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Public Library of Science (PLoS)
2011
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| Accès en ligne: | https://doaj.org/article/951ebe03dc0a4348817dd9503f99674b |
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