Microfluidic active pressure and flow stabiliser

Abstract In microfluidics, a well-known challenge is to obtain reproducible results, often constrained by unstable pressures or flow rates. Today, there are existing stabilisers made for low-pressure microfluidics or high-pressure macrofluidics, often consisting of passive membranes, which cannot st...

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Autores principales:	Simon Södergren, Karolina Svensson, Klas Hjort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/951f523ec4554416b6887e31decfd66d
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spelling	oai:doaj.org-article:951f523ec4554416b6887e31decfd66d2021-11-21T12:20:32ZMicrofluidic active pressure and flow stabiliser10.1038/s41598-021-01865-42045-2322https://doaj.org/article/951f523ec4554416b6887e31decfd66d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01865-4https://doaj.org/toc/2045-2322Abstract In microfluidics, a well-known challenge is to obtain reproducible results, often constrained by unstable pressures or flow rates. Today, there are existing stabilisers made for low-pressure microfluidics or high-pressure macrofluidics, often consisting of passive membranes, which cannot stabilise long-term fluctuations. In this work, a novel stabilisation method that is able to handle high pressures in microfluidics is presented. It is based on upstream flow capacitance and thermal control of the fluid’s viscosity through a PID controlled restrictor-chip. The stabiliser consists of a high-pressure-resistant microfluidic glass chip with integrated thin films, used for resistive heating. Thereby, the stabiliser has no moving parts. The quality of the stabilisation was evaluated with an ISCO pump, an HPLC pump, and a Harvard pump. The stability was greatly improved for all three pumps, with the ISCO reaching the highest relative precision of 0.035% and the best accuracy of 8.0 ppm. Poor accuracy of a pump was compensated for in the control algorithm, as it otherwise reduced the capacity to stabilise longer times. As the dead volume of the stabiliser was only 16 nL, it can be integrated into micro-total-analysis- or other lab-on-a-chip-systems. By this work, a new approach to improve the control of microfluidic systems has been achieved.Simon SödergrenKarolina SvenssonKlas HjortNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simon Södergren Karolina Svensson Klas Hjort Microfluidic active pressure and flow stabiliser
description	Abstract In microfluidics, a well-known challenge is to obtain reproducible results, often constrained by unstable pressures or flow rates. Today, there are existing stabilisers made for low-pressure microfluidics or high-pressure macrofluidics, often consisting of passive membranes, which cannot stabilise long-term fluctuations. In this work, a novel stabilisation method that is able to handle high pressures in microfluidics is presented. It is based on upstream flow capacitance and thermal control of the fluid’s viscosity through a PID controlled restrictor-chip. The stabiliser consists of a high-pressure-resistant microfluidic glass chip with integrated thin films, used for resistive heating. Thereby, the stabiliser has no moving parts. The quality of the stabilisation was evaluated with an ISCO pump, an HPLC pump, and a Harvard pump. The stability was greatly improved for all three pumps, with the ISCO reaching the highest relative precision of 0.035% and the best accuracy of 8.0 ppm. Poor accuracy of a pump was compensated for in the control algorithm, as it otherwise reduced the capacity to stabilise longer times. As the dead volume of the stabiliser was only 16 nL, it can be integrated into micro-total-analysis- or other lab-on-a-chip-systems. By this work, a new approach to improve the control of microfluidic systems has been achieved.
format	article
author	Simon Södergren Karolina Svensson Klas Hjort
author_facet	Simon Södergren Karolina Svensson Klas Hjort
author_sort	Simon Södergren
title	Microfluidic active pressure and flow stabiliser
title_short	Microfluidic active pressure and flow stabiliser
title_full	Microfluidic active pressure and flow stabiliser
title_fullStr	Microfluidic active pressure and flow stabiliser
title_full_unstemmed	Microfluidic active pressure and flow stabiliser
title_sort	microfluidic active pressure and flow stabiliser
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/951f523ec4554416b6887e31decfd66d
work_keys_str_mv	AT simonsodergren microfluidicactivepressureandflowstabiliser AT karolinasvensson microfluidicactivepressureandflowstabiliser AT klashjort microfluidicactivepressureandflowstabiliser
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Microfluidic active pressure and flow stabiliser

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