Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19

Patients with Coronavirus Disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with respiratory issues and related symptoms, in addition to significantly affected digestive system, especially the intestinal tract. While several studies...

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Autores principales:	Zhen-Hua Lu, Hao-Wei Zhou, Wei-Kang Wu, Ting Fu, Min Yan, Zhen He, Shi-Wei Sun, Zhao-Hua Ji, Zhong-jun Shao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 gut virome bacteriome bacteriophage virus-bacteria linkages Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9524c4cffea549bfb4c4648606f7a439
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spelling	oai:doaj.org-article:9524c4cffea549bfb4c4648606f7a4392021-11-30T20:03:55ZAlterations in the Composition of Intestinal DNA Virome in Patients With COVID-192235-298810.3389/fcimb.2021.790422https://doaj.org/article/9524c4cffea549bfb4c4648606f7a4392021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.790422/fullhttps://doaj.org/toc/2235-2988Patients with Coronavirus Disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with respiratory issues and related symptoms, in addition to significantly affected digestive system, especially the intestinal tract. While several studies have shown changes in the intestinal flora of patients with COVID-19, not much information is available on the gut virome of such patients. In this study, we used the viromescan software on the latest gut virome database to analyze the intestinal DNA virome composition of 15 patients with COVID-19 and investigated the characteristic alternations, particularly of the intestinal DNA virome to further explore the influence of COVID-19 on the human gut. The DNA viruses in the gut of patients with COVID-19 were mainly crAss-like phages (35.48%), Myoviridae (20.91%), and Siphoviridae (20.43%) family of viruses. Compared with healthy controls, the gut virome composition of patients with COVID-19 changed significantly, especially the crAss-like phages family, from the first time of hospital admission. A potential correlation is also indicated between the change in virome and bacteriome (like Tectiviridae and Bacteroidaceae). The abundance of the viral and bacterial population was also analyzed through continuous sample collection from the gut of patients hospitalized due to COVID-19. The gut virome is indeed affected by the SARS-CoV-2 infection, and along with gut bacteriome, it may play an important role in the disease progression of COVID-19. These conclusions would be helpful in understanding the gut-related response and contribute to the treatment and prevention strategies of COVID-19.Zhen-Hua LuHao-Wei ZhouHao-Wei ZhouWei-Kang WuWei-Kang WuTing FuMin YanZhen HeShi-Wei SunShi-Wei SunZhao-Hua JiZhong-jun ShaoFrontiers Media S.A.articleCOVID-19gut viromebacteriomebacteriophagevirus-bacteria linkagesMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 gut virome bacteriome bacteriophage virus-bacteria linkages Microbiology QR1-502
spellingShingle	COVID-19 gut virome bacteriome bacteriophage virus-bacteria linkages Microbiology QR1-502 Zhen-Hua Lu Hao-Wei Zhou Hao-Wei Zhou Wei-Kang Wu Wei-Kang Wu Ting Fu Min Yan Zhen He Shi-Wei Sun Shi-Wei Sun Zhao-Hua Ji Zhong-jun Shao Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19
description	Patients with Coronavirus Disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with respiratory issues and related symptoms, in addition to significantly affected digestive system, especially the intestinal tract. While several studies have shown changes in the intestinal flora of patients with COVID-19, not much information is available on the gut virome of such patients. In this study, we used the viromescan software on the latest gut virome database to analyze the intestinal DNA virome composition of 15 patients with COVID-19 and investigated the characteristic alternations, particularly of the intestinal DNA virome to further explore the influence of COVID-19 on the human gut. The DNA viruses in the gut of patients with COVID-19 were mainly crAss-like phages (35.48%), Myoviridae (20.91%), and Siphoviridae (20.43%) family of viruses. Compared with healthy controls, the gut virome composition of patients with COVID-19 changed significantly, especially the crAss-like phages family, from the first time of hospital admission. A potential correlation is also indicated between the change in virome and bacteriome (like Tectiviridae and Bacteroidaceae). The abundance of the viral and bacterial population was also analyzed through continuous sample collection from the gut of patients hospitalized due to COVID-19. The gut virome is indeed affected by the SARS-CoV-2 infection, and along with gut bacteriome, it may play an important role in the disease progression of COVID-19. These conclusions would be helpful in understanding the gut-related response and contribute to the treatment and prevention strategies of COVID-19.
format	article
author	Zhen-Hua Lu Hao-Wei Zhou Hao-Wei Zhou Wei-Kang Wu Wei-Kang Wu Ting Fu Min Yan Zhen He Shi-Wei Sun Shi-Wei Sun Zhao-Hua Ji Zhong-jun Shao
author_facet	Zhen-Hua Lu Hao-Wei Zhou Hao-Wei Zhou Wei-Kang Wu Wei-Kang Wu Ting Fu Min Yan Zhen He Shi-Wei Sun Shi-Wei Sun Zhao-Hua Ji Zhong-jun Shao
author_sort	Zhen-Hua Lu
title	Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19
title_short	Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19
title_full	Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19
title_fullStr	Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19
title_full_unstemmed	Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19
title_sort	alterations in the composition of intestinal dna virome in patients with covid-19
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9524c4cffea549bfb4c4648606f7a439
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Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19

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