The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study

Background. Atopic dermatitis is a chronic multifactorial dermatosis with a complex pathophysiological basis. One of the poorly studied links in the pathogenesis of the disease is endothelin-1. Its main biological effects include pronounced vasoconstriction of blood vessels. Aim. To study the rol...

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Autores principales:	Irina V. Kibalina, Namzhil N. Tsybikov
Formato:	article
Lenguaje:	RU
Publicado:	State Scientific Center of Dermatovenereology and Cosmetology 2021
Materias:	endothelin-1 autoantibodies atopic dermatitis dermographism itch Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/9527d820136342fa9441b5387f165036
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spelling	oai:doaj.org-article:9527d820136342fa9441b5387f1650362021-12-01T22:16:29ZThe role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study0042-46092313-629410.25208/vdv478https://doaj.org/article/9527d820136342fa9441b5387f1650362021-03-01T00:00:00Zhttps://vestnikdv.ru/jour/article/viewFile/478/1164https://doaj.org/toc/0042-4609https://doaj.org/toc/2313-6294Background. Atopic dermatitis is a chronic multifactorial dermatosis with a complex pathophysiological basis. One of the poorly studied links in the pathogenesis of the disease is endothelin-1. Its main biological effects include pronounced vasoconstriction of blood vessels. Aim. To study the role of endothelin-1 and its autoantibodies in the pathogenesis of atopic dermatitis. Materials and methods. The study included 40 patients with common and limited forms of atopic dermatitis in the period of exacerbation and remission. The concentration of endothelin-1 and autoantibodies to it in the blood serum was determined by the ELISA method. Statistical processing of the obtained data was performed using Statistica 6.0. Statistical significance was determined at p 0.05. Results. High concentrations of endothelin-1 and autoantibodies to it were determined during the exacerbation of the disease. When the clinical picture was resolved; the concentration of endothelin-1 and autoantibodies to it significantly decreased; but remained higher than the control group. Based on the data obtained; it can be assumed that an increase in the concentration of endothelin-1 may be a marker of white dermographism and a regulator of the microcirculation process in the skin. Conclusions. A high level of endothelin-1 contributes to the development of inflammatory reactions in the skin; white dermographism and itching. Endothelin-1 receptors may be potential aim for targeted therapy of atopic dermatitis.Irina V. KibalinaNamzhil N. TsybikovState Scientific Center of Dermatovenereology and Cosmetologyarticleendothelin-1autoantibodiesatopic dermatitisdermographismitchDermatologyRL1-803RUVestnik Dermatologii i Venerologii, Vol 97, Iss 1, Pp 34-40 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	endothelin-1 autoantibodies atopic dermatitis dermographism itch Dermatology RL1-803
spellingShingle	endothelin-1 autoantibodies atopic dermatitis dermographism itch Dermatology RL1-803 Irina V. Kibalina Namzhil N. Tsybikov The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study
description	Background. Atopic dermatitis is a chronic multifactorial dermatosis with a complex pathophysiological basis. One of the poorly studied links in the pathogenesis of the disease is endothelin-1. Its main biological effects include pronounced vasoconstriction of blood vessels. Aim. To study the role of endothelin-1 and its autoantibodies in the pathogenesis of atopic dermatitis. Materials and methods. The study included 40 patients with common and limited forms of atopic dermatitis in the period of exacerbation and remission. The concentration of endothelin-1 and autoantibodies to it in the blood serum was determined by the ELISA method. Statistical processing of the obtained data was performed using Statistica 6.0. Statistical significance was determined at p 0.05. Results. High concentrations of endothelin-1 and autoantibodies to it were determined during the exacerbation of the disease. When the clinical picture was resolved; the concentration of endothelin-1 and autoantibodies to it significantly decreased; but remained higher than the control group. Based on the data obtained; it can be assumed that an increase in the concentration of endothelin-1 may be a marker of white dermographism and a regulator of the microcirculation process in the skin. Conclusions. A high level of endothelin-1 contributes to the development of inflammatory reactions in the skin; white dermographism and itching. Endothelin-1 receptors may be potential aim for targeted therapy of atopic dermatitis.
format	article
author	Irina V. Kibalina Namzhil N. Tsybikov
author_facet	Irina V. Kibalina Namzhil N. Tsybikov
author_sort	Irina V. Kibalina
title	The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study
title_short	The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study
title_full	The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study
title_fullStr	The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study
title_full_unstemmed	The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study
title_sort	role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study
publisher	State Scientific Center of Dermatovenereology and Cosmetology
publishDate	2021
url	https://doaj.org/article/9527d820136342fa9441b5387f165036
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The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study

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