The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review

With the aging population, dementia emerges as a public health concern. In 2012, the Health and Retirement Study found that 8.8% of adults over 65 years suffered from dementia. The etiopathogenesis and treatment of dementia are not well understood. Antioxidant properties of Vitamin E and its major e...

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Autores principales:	Ram Lakhan, Manoj Sharma, Kavita Batra, Frazier B. Beatty
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dementia mild cognitive impairment vitamin E amnesia Medicine R
Acceso en línea:	https://doaj.org/article/9528e1cc8b604079b7d6a2f86618eb73
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spelling	oai:doaj.org-article:9528e1cc8b604079b7d6a2f86618eb732021-11-25T17:46:30ZThe Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review10.3390/healthcare91115732227-9032https://doaj.org/article/9528e1cc8b604079b7d6a2f86618eb732021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1573https://doaj.org/toc/2227-9032With the aging population, dementia emerges as a public health concern. In 2012, the Health and Retirement Study found that 8.8% of adults over 65 years suffered from dementia. The etiopathogenesis and treatment of dementia are not well understood. Antioxidant properties of Vitamin E and its major elements tocopherols and tocotrienols have been reported to be effective in slowing down the progression of dementia from its initial stage of Mild cognitive impairment (MCI). Therefore, the current review aims to explore the role of vitamin E on MCI. A literature search using the key words “Vitamin E, tocopherols, tocotrienols, and mild cognitive impairment” was conducted in MEDLINE (PubMed), CINAHL, and Google Scholar. The inclusion criteria were: (1) articles published in the past ten years; (2) published in English language; (3) published in peer-reviewed journals; and (4) descriptive and epidemiological or evaluation studies. Articles published prior to 2010, focused on other forms of dementia than MCI, grey literature and non-peer-reviewed articles were excluded. A total of 22 studies were included in the narrative synthesis. The results were equivocal. Eleven studies showed some level of the neuroprotective effect of Vitamin E, tocopherols and tocotrienols on the progression of MCI. The mixed results of this review suggest further exploration of the possible protective effects of Vitamin E on the development of dementia. Future studies can be conducted to decipher antioxidant properties of vitamin E and its association with slowing down the cognitive decline.Ram LakhanManoj SharmaKavita BatraFrazier B. BeattyMDPI AGarticledementiamild cognitive impairmentvitamin EamnesiaMedicineRENHealthcare, Vol 9, Iss 1573, p 1573 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dementia mild cognitive impairment vitamin E amnesia Medicine R
spellingShingle	dementia mild cognitive impairment vitamin E amnesia Medicine R Ram Lakhan Manoj Sharma Kavita Batra Frazier B. Beatty The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review
description	With the aging population, dementia emerges as a public health concern. In 2012, the Health and Retirement Study found that 8.8% of adults over 65 years suffered from dementia. The etiopathogenesis and treatment of dementia are not well understood. Antioxidant properties of Vitamin E and its major elements tocopherols and tocotrienols have been reported to be effective in slowing down the progression of dementia from its initial stage of Mild cognitive impairment (MCI). Therefore, the current review aims to explore the role of vitamin E on MCI. A literature search using the key words “Vitamin E, tocopherols, tocotrienols, and mild cognitive impairment” was conducted in MEDLINE (PubMed), CINAHL, and Google Scholar. The inclusion criteria were: (1) articles published in the past ten years; (2) published in English language; (3) published in peer-reviewed journals; and (4) descriptive and epidemiological or evaluation studies. Articles published prior to 2010, focused on other forms of dementia than MCI, grey literature and non-peer-reviewed articles were excluded. A total of 22 studies were included in the narrative synthesis. The results were equivocal. Eleven studies showed some level of the neuroprotective effect of Vitamin E, tocopherols and tocotrienols on the progression of MCI. The mixed results of this review suggest further exploration of the possible protective effects of Vitamin E on the development of dementia. Future studies can be conducted to decipher antioxidant properties of vitamin E and its association with slowing down the cognitive decline.
format	article
author	Ram Lakhan Manoj Sharma Kavita Batra Frazier B. Beatty
author_facet	Ram Lakhan Manoj Sharma Kavita Batra Frazier B. Beatty
author_sort	Ram Lakhan
title	The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review
title_short	The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review
title_full	The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review
title_fullStr	The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review
title_full_unstemmed	The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review
title_sort	role of vitamin e in slowing down mild cognitive impairment: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9528e1cc8b604079b7d6a2f86618eb73
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The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review

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