A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019

Abstract Diagnosis of pediatric paragonimiasis is difficult because of its non-specific clinical manifestations. We retrospectively reviewed the records of pediatric paragonimiasis in Children’s Hospital of Fudan University from January 2011 to May 2019. The confirmed diagnosis of paragonimiasis was...

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Autores principales:	Manning Qian, Fei Li, Yuhan Zhang, Zhongwei Qiao, Yingyan Shi, Jun Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/952e18f3f8fe46feb15b67a11b070b26
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spelling	oai:doaj.org-article:952e18f3f8fe46feb15b67a11b070b262021-12-02T11:50:30ZA retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 201910.1038/s41598-021-81694-72045-2322https://doaj.org/article/952e18f3f8fe46feb15b67a11b070b262021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81694-7https://doaj.org/toc/2045-2322Abstract Diagnosis of pediatric paragonimiasis is difficult because of its non-specific clinical manifestations. We retrospectively reviewed the records of pediatric paragonimiasis in Children’s Hospital of Fudan University from January 2011 to May 2019. The confirmed diagnosis of paragonimiasis was based on positive anti-parasite serological tests from the local Center for Disease Control (CDC). A total of 11 patients (mean age: 7.7 ± 3.1, male–female ratio: 7:4) diagnosed as paragonimiasis were included. 81.8% were from endemic areas such as Sichuan and Yunnan, and 36% had a clear history of raw crab or crayfish consumption. The characteristic clinical features of pediatric paragonimiasis were eosinophilia (100%), pleural effusion (81.8%), hepatomegaly (54.5%), ascites (54.5%), and subcutaneous nodules (45.5%). Misdiagnosed with other diseases including tuberculosis (18.2%), pneumonia (9.1%), intracranial space-occupying lesions (9.1%) and brain abcess (9.1%) led to rehospitalization and prolonged hospitalization. For treatment, a 3-day course of 150 mg/kg praziquantel (PZQ) didn’t show ideal treatment effectivity and 63.6% needed more than one course of PZQ, while triclabendazole in a total dose of 10 mg/kg had a better efficacy to stubborn manifestations. This study indicated that pediatric paragonimiasis was often misdiagnosed, and the treatment with a 3-day course of 150 mg/kg PZQ had a high rate of failure.Manning QianFei LiYuhan ZhangZhongwei QiaoYingyan ShiJun ShenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manning Qian Fei Li Yuhan Zhang Zhongwei Qiao Yingyan Shi Jun Shen A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019
description	Abstract Diagnosis of pediatric paragonimiasis is difficult because of its non-specific clinical manifestations. We retrospectively reviewed the records of pediatric paragonimiasis in Children’s Hospital of Fudan University from January 2011 to May 2019. The confirmed diagnosis of paragonimiasis was based on positive anti-parasite serological tests from the local Center for Disease Control (CDC). A total of 11 patients (mean age: 7.7 ± 3.1, male–female ratio: 7:4) diagnosed as paragonimiasis were included. 81.8% were from endemic areas such as Sichuan and Yunnan, and 36% had a clear history of raw crab or crayfish consumption. The characteristic clinical features of pediatric paragonimiasis were eosinophilia (100%), pleural effusion (81.8%), hepatomegaly (54.5%), ascites (54.5%), and subcutaneous nodules (45.5%). Misdiagnosed with other diseases including tuberculosis (18.2%), pneumonia (9.1%), intracranial space-occupying lesions (9.1%) and brain abcess (9.1%) led to rehospitalization and prolonged hospitalization. For treatment, a 3-day course of 150 mg/kg praziquantel (PZQ) didn’t show ideal treatment effectivity and 63.6% needed more than one course of PZQ, while triclabendazole in a total dose of 10 mg/kg had a better efficacy to stubborn manifestations. This study indicated that pediatric paragonimiasis was often misdiagnosed, and the treatment with a 3-day course of 150 mg/kg PZQ had a high rate of failure.
format	article
author	Manning Qian Fei Li Yuhan Zhang Zhongwei Qiao Yingyan Shi Jun Shen
author_facet	Manning Qian Fei Li Yuhan Zhang Zhongwei Qiao Yingyan Shi Jun Shen
author_sort	Manning Qian
title	A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019
title_short	A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019
title_full	A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019
title_fullStr	A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019
title_full_unstemmed	A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019
title_sort	retrospective clinical analysis of pediatric paragonimiasis in a chinese children’s hospital from 2011 to 2019
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/952e18f3f8fe46feb15b67a11b070b26
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A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019

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