High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin

α1-Antitrypsin (AAT) is a 52 kDa serum glycoprotein, the misfolding and polymerisation of which is associated with COPD and liver disease. Here the authors demonstrate the use of high-resolution multidimensional solution-state NMR spectroscopy to characterise the structure and dynamics in solution o...

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Autores principales:	Alistair M. Jagger, Christopher A. Waudby, James A. Irving, John Christodoulou, David A. Lomas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/952ff70a4c194a3cb72bb437aed03968
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spelling	oai:doaj.org-article:952ff70a4c194a3cb72bb437aed039682021-12-02T10:48:28ZHigh-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin10.1038/s41467-020-20147-72041-1723https://doaj.org/article/952ff70a4c194a3cb72bb437aed039682020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20147-7https://doaj.org/toc/2041-1723α1-Antitrypsin (AAT) is a 52 kDa serum glycoprotein, the misfolding and polymerisation of which is associated with COPD and liver disease. Here the authors demonstrate the use of high-resolution multidimensional solution-state NMR spectroscopy to characterise the structure and dynamics in solution of Z AAT purified directly from clinical patients.Alistair M. JaggerChristopher A. WaudbyJames A. IrvingJohn ChristodoulouDavid A. LomasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alistair M. Jagger Christopher A. Waudby James A. Irving John Christodoulou David A. Lomas High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin
description	α1-Antitrypsin (AAT) is a 52 kDa serum glycoprotein, the misfolding and polymerisation of which is associated with COPD and liver disease. Here the authors demonstrate the use of high-resolution multidimensional solution-state NMR spectroscopy to characterise the structure and dynamics in solution of Z AAT purified directly from clinical patients.
format	article
author	Alistair M. Jagger Christopher A. Waudby James A. Irving John Christodoulou David A. Lomas
author_facet	Alistair M. Jagger Christopher A. Waudby James A. Irving John Christodoulou David A. Lomas
author_sort	Alistair M. Jagger
title	High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin
title_short	High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin
title_full	High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin
title_fullStr	High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin
title_full_unstemmed	High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin
title_sort	high-resolution ex vivo nmr spectroscopy of human z α1-antitrypsin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/952ff70a4c194a3cb72bb437aed03968
work_keys_str_mv	AT alistairmjagger highresolutionexvivonmrspectroscopyofhumanza1antitrypsin AT christopherawaudby highresolutionexvivonmrspectroscopyofhumanza1antitrypsin AT jamesairving highresolutionexvivonmrspectroscopyofhumanza1antitrypsin AT johnchristodoulou highresolutionexvivonmrspectroscopyofhumanza1antitrypsin AT davidalomas highresolutionexvivonmrspectroscopyofhumanza1antitrypsin
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High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin

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