Transient opening of trimeric prefusion RSV F proteins

The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in transient opening of the trimeric complex in solut...

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Autores principales:	Morgan S. A. Gilman, Polina Furmanova-Hollenstein, Gabriel Pascual, Angélique B. van ‘t Wout, Johannes P. M. Langedijk, Jason S. McLellan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9532301d0812415caee29f9be8ded047
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spelling	oai:doaj.org-article:9532301d0812415caee29f9be8ded0472021-12-02T16:58:05ZTransient opening of trimeric prefusion RSV F proteins10.1038/s41467-019-09807-52041-1723https://doaj.org/article/9532301d0812415caee29f9be8ded0472019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09807-5https://doaj.org/toc/2041-1723The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in transient opening of the trimeric complex in solution and on the cell surface.Morgan S. A. GilmanPolina Furmanova-HollensteinGabriel PascualAngélique B. van ‘t WoutJohannes P. M. LangedijkJason S. McLellanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Morgan S. A. Gilman Polina Furmanova-Hollenstein Gabriel Pascual Angélique B. van ‘t Wout Johannes P. M. Langedijk Jason S. McLellan Transient opening of trimeric prefusion RSV F proteins
description	The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in transient opening of the trimeric complex in solution and on the cell surface.
format	article
author	Morgan S. A. Gilman Polina Furmanova-Hollenstein Gabriel Pascual Angélique B. van ‘t Wout Johannes P. M. Langedijk Jason S. McLellan
author_facet	Morgan S. A. Gilman Polina Furmanova-Hollenstein Gabriel Pascual Angélique B. van ‘t Wout Johannes P. M. Langedijk Jason S. McLellan
author_sort	Morgan S. A. Gilman
title	Transient opening of trimeric prefusion RSV F proteins
title_short	Transient opening of trimeric prefusion RSV F proteins
title_full	Transient opening of trimeric prefusion RSV F proteins
title_fullStr	Transient opening of trimeric prefusion RSV F proteins
title_full_unstemmed	Transient opening of trimeric prefusion RSV F proteins
title_sort	transient opening of trimeric prefusion rsv f proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9532301d0812415caee29f9be8ded047
work_keys_str_mv	AT morgansagilman transientopeningoftrimericprefusionrsvfproteins AT polinafurmanovahollenstein transientopeningoftrimericprefusionrsvfproteins AT gabrielpascual transientopeningoftrimericprefusionrsvfproteins AT angeliquebvantwout transientopeningoftrimericprefusionrsvfproteins AT johannespmlangedijk transientopeningoftrimericprefusionrsvfproteins AT jasonsmclellan transientopeningoftrimericprefusionrsvfproteins
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Transient opening of trimeric prefusion RSV F proteins

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