The molecular basis of regulation of bacterial capsule assembly by Wzc

The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc octamer and provide insight into its regulation through...

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Auteurs principaux: Yun Yang, Jiwei Liu, Bradley R. Clarke, Laura Seidel, Jani R. Bolla, Philip N. Ward, Peijun Zhang, Carol V. Robinson, Chris Whitfield, James H. Naismith
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/953375ccf8f24a0f97419d2d1888d0c0
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Résumé:The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc octamer and provide insight into its regulation through phosphorylation.