Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration

Dimitrios Karagiannis,1 Irini Chatziralli,1 Konstantinos Kaprinis,1 Ilias Georgalas,2 Efstratios Parikakis,1 Panagiotis Mitropoulos1 1Second Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece; 2First Department of Ophthalmology, University of Athens, Athens, Greece Purpose: To ev...

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Autores principales:	Karagiannis D, Chatziralli I, Kaprinis K, Georgalas I, Parikakis E, Mitropoulos P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Age-related macular degeneration ranibizumab submacular hemorrhage treatment Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/95388962b20a4e7999776faddcf1b08b
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spelling	oai:doaj.org-article:95388962b20a4e7999776faddcf1b08b2021-12-02T00:29:15ZLocation of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration1178-1998https://doaj.org/article/95388962b20a4e7999776faddcf1b08b2017-11-01T00:00:00Zhttps://www.dovepress.com/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-aft-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Dimitrios Karagiannis,1 Irini Chatziralli,1 Konstantinos Kaprinis,1 Ilias Georgalas,2 Efstratios Parikakis,1 Panagiotis Mitropoulos1 1Second Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece; 2First Department of Ophthalmology, University of Athens, Athens, Greece Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months’ follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter. Results: Of the patients, 83.4% showed improvement or stabilization in best-corrected visual acuity after treatment at the 12-month follow-up, with a mean number of 7.3±2.9 injections. Patients with SMH surrounding the foveal area in 360° presented worse anatomical and functional outcomes compared to those with SMH adjacent to the fovea. Conclusion: Intravitreal ranibizumab seems to be safe and effective, either improving or stabilizing visual acuity, in patients with SMH due to wet AMD. The location of the SMH may predict the final outcome after treatment. Keywords: age-related macular degeneration, ranibizumab, submacular hemorrhage, treatmentKaragiannis DChatziralli IKaprinis KGeorgalas IParikakis EMitropoulos PDove Medical PressarticleAge-related macular degenerationranibizumabsubmacular hemorrhagetreatmentGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1829-1833 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Age-related macular degeneration ranibizumab submacular hemorrhage treatment Geriatrics RC952-954.6
spellingShingle	Age-related macular degeneration ranibizumab submacular hemorrhage treatment Geriatrics RC952-954.6 Karagiannis D Chatziralli I Kaprinis K Georgalas I Parikakis E Mitropoulos P Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
description	Dimitrios Karagiannis,1 Irini Chatziralli,1 Konstantinos Kaprinis,1 Ilias Georgalas,2 Efstratios Parikakis,1 Panagiotis Mitropoulos1 1Second Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece; 2First Department of Ophthalmology, University of Athens, Athens, Greece Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months’ follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter. Results: Of the patients, 83.4% showed improvement or stabilization in best-corrected visual acuity after treatment at the 12-month follow-up, with a mean number of 7.3±2.9 injections. Patients with SMH surrounding the foveal area in 360° presented worse anatomical and functional outcomes compared to those with SMH adjacent to the fovea. Conclusion: Intravitreal ranibizumab seems to be safe and effective, either improving or stabilizing visual acuity, in patients with SMH due to wet AMD. The location of the SMH may predict the final outcome after treatment. Keywords: age-related macular degeneration, ranibizumab, submacular hemorrhage, treatment
format	article
author	Karagiannis D Chatziralli I Kaprinis K Georgalas I Parikakis E Mitropoulos P
author_facet	Karagiannis D Chatziralli I Kaprinis K Georgalas I Parikakis E Mitropoulos P
author_sort	Karagiannis D
title	Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
title_short	Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
title_full	Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
title_fullStr	Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
title_full_unstemmed	Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
title_sort	location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/95388962b20a4e7999776faddcf1b08b
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Location of submacular hemorrhage as a predictor of visual outcome after intravitreal ranibizumab for age-related macular degeneration

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