Near-infrared spectroscopy as a tool for in vivo analysis of human muscles

Abstract Recent advances in materials and fabrication techniques provided portable, performant, sensing optical spectrometers readily operated by user-friendly cabled or wireless systems. Such systems allow rapid, non-invasive, and not destructive quantitative analysis of human tissues. This proof-o...

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Autores principales:	Antonio Currà, Riccardo Gasbarrone, Alessandra Cardillo, Carlo Trompetto, Francesco Fattapposta, Francesco Pierelli, Paolo Missori, Giuseppe Bonifazi, Silvia Serranti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9538bae76e1e40159c63ef998c4c069a
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spelling	oai:doaj.org-article:9538bae76e1e40159c63ef998c4c069a2021-12-02T15:08:47ZNear-infrared spectroscopy as a tool for in vivo analysis of human muscles10.1038/s41598-019-44896-82045-2322https://doaj.org/article/9538bae76e1e40159c63ef998c4c069a2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44896-8https://doaj.org/toc/2045-2322Abstract Recent advances in materials and fabrication techniques provided portable, performant, sensing optical spectrometers readily operated by user-friendly cabled or wireless systems. Such systems allow rapid, non-invasive, and not destructive quantitative analysis of human tissues. This proof-of-principle investigation tested whether infrared spectroscopy techniques, currently utilized in a variety of areas, could be applied in living humans to categorize muscles. Using an ASD FieldSpec® 4 Standard-Res Spectroradiometer with a spectral sampling capability of 1.4 nm at 350–1000 nm and 1.1 nm at 1001–2500 nm, we acquired reflectance spectra in visible short-wave infra-red regions (350–2500 nm) from the upper limb muscles (flexors and extensors) of 20 healthy subjects (age 25–89 years, 9 women). Spectra off-line analysis included preliminary preprocessing, Principal Component Analysis, and Partial Least-Squares Discriminant Analysis. Near-infrared (NIR) spectroscopy proved valuable for noninvasive assessment of tissue optical properties in vivo. In addition to the non-invasive detection of tissue oxygenation, NIR spectroscopy provided the spectral signatures (ie, “fingerprints”) of upper limb flexors and extensors, which represent specific, accurate, and reproducible measures of the overall biological status of these muscles. Thus, non-invasive NIR spectroscopy enables more thorough evaluation of the muscular system and optimal monitoring of the effectiveness of therapeutic or rehabilitative interventions.Antonio CurràRiccardo GasbarroneAlessandra CardilloCarlo TrompettoFrancesco FattappostaFrancesco PierelliPaolo MissoriGiuseppe BonifaziSilvia SerrantiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonio Currà Riccardo Gasbarrone Alessandra Cardillo Carlo Trompetto Francesco Fattapposta Francesco Pierelli Paolo Missori Giuseppe Bonifazi Silvia Serranti Near-infrared spectroscopy as a tool for in vivo analysis of human muscles
description	Abstract Recent advances in materials and fabrication techniques provided portable, performant, sensing optical spectrometers readily operated by user-friendly cabled or wireless systems. Such systems allow rapid, non-invasive, and not destructive quantitative analysis of human tissues. This proof-of-principle investigation tested whether infrared spectroscopy techniques, currently utilized in a variety of areas, could be applied in living humans to categorize muscles. Using an ASD FieldSpec® 4 Standard-Res Spectroradiometer with a spectral sampling capability of 1.4 nm at 350–1000 nm and 1.1 nm at 1001–2500 nm, we acquired reflectance spectra in visible short-wave infra-red regions (350–2500 nm) from the upper limb muscles (flexors and extensors) of 20 healthy subjects (age 25–89 years, 9 women). Spectra off-line analysis included preliminary preprocessing, Principal Component Analysis, and Partial Least-Squares Discriminant Analysis. Near-infrared (NIR) spectroscopy proved valuable for noninvasive assessment of tissue optical properties in vivo. In addition to the non-invasive detection of tissue oxygenation, NIR spectroscopy provided the spectral signatures (ie, “fingerprints”) of upper limb flexors and extensors, which represent specific, accurate, and reproducible measures of the overall biological status of these muscles. Thus, non-invasive NIR spectroscopy enables more thorough evaluation of the muscular system and optimal monitoring of the effectiveness of therapeutic or rehabilitative interventions.
format	article
author	Antonio Currà Riccardo Gasbarrone Alessandra Cardillo Carlo Trompetto Francesco Fattapposta Francesco Pierelli Paolo Missori Giuseppe Bonifazi Silvia Serranti
author_facet	Antonio Currà Riccardo Gasbarrone Alessandra Cardillo Carlo Trompetto Francesco Fattapposta Francesco Pierelli Paolo Missori Giuseppe Bonifazi Silvia Serranti
author_sort	Antonio Currà
title	Near-infrared spectroscopy as a tool for in vivo analysis of human muscles
title_short	Near-infrared spectroscopy as a tool for in vivo analysis of human muscles
title_full	Near-infrared spectroscopy as a tool for in vivo analysis of human muscles
title_fullStr	Near-infrared spectroscopy as a tool for in vivo analysis of human muscles
title_full_unstemmed	Near-infrared spectroscopy as a tool for in vivo analysis of human muscles
title_sort	near-infrared spectroscopy as a tool for in vivo analysis of human muscles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9538bae76e1e40159c63ef998c4c069a
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Near-infrared spectroscopy as a tool for in vivo analysis of human muscles

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