Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts

Benzylic functionalisation of unactivated toluenes remains a challenge in asymmetric catalysis. Here a chiral Brønsted base catalyses the enantioselective C(sp3)-H functionalization of unactivated alkylarenes, enabling carbon-carbon bond formation at benzylic positions of toluene derivatives.

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Autores principales:	Tsubasa Hirata, Io Sato, Yasuhiro Yamashita, Shū Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9539fd65b1104cd5b231246152e7078f
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spelling	oai:doaj.org-article:9539fd65b1104cd5b231246152e7078f2021-12-02T16:30:39ZAsymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts10.1038/s42004-021-00459-52399-3669https://doaj.org/article/9539fd65b1104cd5b231246152e7078f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00459-5https://doaj.org/toc/2399-3669Benzylic functionalisation of unactivated toluenes remains a challenge in asymmetric catalysis. Here a chiral Brønsted base catalyses the enantioselective C(sp3)-H functionalization of unactivated alkylarenes, enabling carbon-carbon bond formation at benzylic positions of toluene derivatives.Tsubasa HirataIo SatoYasuhiro YamashitaShū KobayashiNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Tsubasa Hirata Io Sato Yasuhiro Yamashita Shū Kobayashi Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts
description	Benzylic functionalisation of unactivated toluenes remains a challenge in asymmetric catalysis. Here a chiral Brønsted base catalyses the enantioselective C(sp3)-H functionalization of unactivated alkylarenes, enabling carbon-carbon bond formation at benzylic positions of toluene derivatives.
format	article
author	Tsubasa Hirata Io Sato Yasuhiro Yamashita Shū Kobayashi
author_facet	Tsubasa Hirata Io Sato Yasuhiro Yamashita Shū Kobayashi
author_sort	Tsubasa Hirata
title	Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts
title_short	Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts
title_full	Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts
title_fullStr	Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts
title_full_unstemmed	Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts
title_sort	asymmetric c(sp3)–h functionalization of unactivated alkylarenes such as toluene enabled by chiral brønsted base catalysts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9539fd65b1104cd5b231246152e7078f
work_keys_str_mv	AT tsubasahirata asymmetriccsp3hfunctionalizationofunactivatedalkylarenessuchastolueneenabledbychiralbrønstedbasecatalysts AT iosato asymmetriccsp3hfunctionalizationofunactivatedalkylarenessuchastolueneenabledbychiralbrønstedbasecatalysts AT yasuhiroyamashita asymmetriccsp3hfunctionalizationofunactivatedalkylarenessuchastolueneenabledbychiralbrønstedbasecatalysts AT shukobayashi asymmetriccsp3hfunctionalizationofunactivatedalkylarenessuchastolueneenabledbychiralbrønstedbasecatalysts
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Asymmetric C(sp3)–H functionalization of unactivated alkylarenes such as toluene enabled by chiral Brønsted base catalysts

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