Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes

Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.

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Autores principales:	Koichi Takahashi, Feng Wang, Kiyomi Morita, Yuanqing Yan, Peter Hu, Pei Zhao, Abdallah Abou Zhar, Chang Jiun Wu, Curtis Gumbs, Latasha Little, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Marisela Mendoza, Erika Thompson, Jianhua Zhang, Courtney D. DiNardo, Nitin Jain, Farhad Ravandi, Jorge E. Cortes, Guillermo Garcia-Manero, Steven Kornblau, Michael Andreeff, Elias Jabbour, Carlos Bueso-Ramos, Akifumi Takaori-Kondo, Marina Konopleva, Keyur Patel, Hagop Kantarjian, P. Andrew Futreal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/953fd20186754223976bbb7a89f2b1cf
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spelling	oai:doaj.org-article:953fd20186754223976bbb7a89f2b1cf2021-12-02T15:34:50ZIntegrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes10.1038/s41467-018-04924-z2041-1723https://doaj.org/article/953fd20186754223976bbb7a89f2b1cf2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04924-zhttps://doaj.org/toc/2041-1723Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.Koichi TakahashiFeng WangKiyomi MoritaYuanqing YanPeter HuPei ZhaoAbdallah Abou ZharChang Jiun WuCurtis GumbsLatasha LittleSamantha TippenRebecca ThorntonMarcus CoyleMarisela MendozaErika ThompsonJianhua ZhangCourtney D. DiNardoNitin JainFarhad RavandiJorge E. CortesGuillermo Garcia-ManeroSteven KornblauMichael AndreeffElias JabbourCarlos Bueso-RamosAkifumi Takaori-KondoMarina KonoplevaKeyur PatelHagop KantarjianP. Andrew FutrealNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koichi Takahashi Feng Wang Kiyomi Morita Yuanqing Yan Peter Hu Pei Zhao Abdallah Abou Zhar Chang Jiun Wu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Marcus Coyle Marisela Mendoza Erika Thompson Jianhua Zhang Courtney D. DiNardo Nitin Jain Farhad Ravandi Jorge E. Cortes Guillermo Garcia-Manero Steven Kornblau Michael Andreeff Elias Jabbour Carlos Bueso-Ramos Akifumi Takaori-Kondo Marina Konopleva Keyur Patel Hagop Kantarjian P. Andrew Futreal Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
description	Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.
format	article
author	Koichi Takahashi Feng Wang Kiyomi Morita Yuanqing Yan Peter Hu Pei Zhao Abdallah Abou Zhar Chang Jiun Wu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Marcus Coyle Marisela Mendoza Erika Thompson Jianhua Zhang Courtney D. DiNardo Nitin Jain Farhad Ravandi Jorge E. Cortes Guillermo Garcia-Manero Steven Kornblau Michael Andreeff Elias Jabbour Carlos Bueso-Ramos Akifumi Takaori-Kondo Marina Konopleva Keyur Patel Hagop Kantarjian P. Andrew Futreal
author_facet	Koichi Takahashi Feng Wang Kiyomi Morita Yuanqing Yan Peter Hu Pei Zhao Abdallah Abou Zhar Chang Jiun Wu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Marcus Coyle Marisela Mendoza Erika Thompson Jianhua Zhang Courtney D. DiNardo Nitin Jain Farhad Ravandi Jorge E. Cortes Guillermo Garcia-Manero Steven Kornblau Michael Andreeff Elias Jabbour Carlos Bueso-Ramos Akifumi Takaori-Kondo Marina Konopleva Keyur Patel Hagop Kantarjian P. Andrew Futreal
author_sort	Koichi Takahashi
title	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_short	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_full	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_fullStr	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_full_unstemmed	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_sort	integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/953fd20186754223976bbb7a89f2b1cf
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Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes

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