RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response.

RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response.

The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-tuned to maintain immune homeostasis in antiviral r...

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Autores principales: Chenhui Li, Lele Zhang, Dong Qian, Mingxing Cheng, Haiyang Hu, Ze Hong, Ye Cui, Huansha Yu, Quanyi Wang, Juanjuan Zhu, Wei Meng, Jin-Fu Xu, Yi Sun, Peng Zhang, Chen Wang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/95401f6be3be41ad98586ad3bb65d14b
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