Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.

<h4>Background</h4>MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor sup...

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Autores principales:	Masami Tanaka, Kosuke Oikawa, Masakatsu Takanashi, Motoshige Kudo, Junko Ohyashiki, Kazuma Ohyashiki, Masahiko Kuroda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9545094012c8422498e3a1d54d6eb1c0
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spelling	oai:doaj.org-article:9545094012c8422498e3a1d54d6eb1c02021-11-25T06:22:41ZDown-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.1932-620310.1371/journal.pone.0005532https://doaj.org/article/9545094012c8422498e3a1d54d6eb1c02009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19440243/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite this knowledge, there is little information regarding microRNAs in plasma especially because microRNAs in plasma, if exist, were thought to be digested by RNase. Recent studies, however, have revealed that microRNAs exist and escape digestion in plasma.<h4>Methodology/principal findings</h4>We performed microRNA microaray to obtain insight into microRNA deregulation in the plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a (miR-92a) dramatically decreased in the plasmas of acute leukemia patients. Especially, the ratio of miR-92a/miR-638 in plasma was very useful for distinguishing leukemia patients from healthy body.<h4>Conclusions/significance</h4>The ratio of miR-92a/miR-638 in plasma has strong potential for clinical application as a novel biomarker for detection of leukemia.Masami TanakaKosuke OikawaMasakatsu TakanashiMotoshige KudoJunko OhyashikiKazuma OhyashikiMasahiko KurodaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 5, p e5532 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masami Tanaka Kosuke Oikawa Masakatsu Takanashi Motoshige Kudo Junko Ohyashiki Kazuma Ohyashiki Masahiko Kuroda Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.
description	<h4>Background</h4>MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite this knowledge, there is little information regarding microRNAs in plasma especially because microRNAs in plasma, if exist, were thought to be digested by RNase. Recent studies, however, have revealed that microRNAs exist and escape digestion in plasma.<h4>Methodology/principal findings</h4>We performed microRNA microaray to obtain insight into microRNA deregulation in the plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a (miR-92a) dramatically decreased in the plasmas of acute leukemia patients. Especially, the ratio of miR-92a/miR-638 in plasma was very useful for distinguishing leukemia patients from healthy body.<h4>Conclusions/significance</h4>The ratio of miR-92a/miR-638 in plasma has strong potential for clinical application as a novel biomarker for detection of leukemia.
format	article
author	Masami Tanaka Kosuke Oikawa Masakatsu Takanashi Motoshige Kudo Junko Ohyashiki Kazuma Ohyashiki Masahiko Kuroda
author_facet	Masami Tanaka Kosuke Oikawa Masakatsu Takanashi Motoshige Kudo Junko Ohyashiki Kazuma Ohyashiki Masahiko Kuroda
author_sort	Masami Tanaka
title	Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.
title_short	Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.
title_full	Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.
title_fullStr	Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.
title_full_unstemmed	Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.
title_sort	down-regulation of mir-92 in human plasma is a novel marker for acute leukemia patients.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/9545094012c8422498e3a1d54d6eb1c0
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Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.

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