Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Inflammasome activation is a response to bacterial infection but can cause damage and spread infection. Here, the authors use live single-cell imaging to show two mechanisms by which M. tuberculosis causes damage to human macrophage cell plasma membranes, resulting in activation of the NLRP3 inflamm...

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Auteurs principaux:	Kai S. Beckwith, Marianne S. Beckwith, Sindre Ullmann, Ragnhild S. Sætra, Haelin Kim, Anne Marstad, Signe E. Åsberg, Trine A. Strand, Markus Haug, Michael Niederweis, Harald A. Stenmark, Trude H. Flo
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9546bc66dd1e4c0bb737b9ca565a8f54
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spelling	oai:doaj.org-article:9546bc66dd1e4c0bb737b9ca565a8f542021-12-02T17:32:57ZPlasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection10.1038/s41467-020-16143-62041-1723https://doaj.org/article/9546bc66dd1e4c0bb737b9ca565a8f542020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16143-6https://doaj.org/toc/2041-1723Inflammasome activation is a response to bacterial infection but can cause damage and spread infection. Here, the authors use live single-cell imaging to show two mechanisms by which M. tuberculosis causes damage to human macrophage cell plasma membranes, resulting in activation of the NLRP3 inflammasome, pyroptosis and release of infectious particles.Kai S. BeckwithMarianne S. BeckwithSindre UllmannRagnhild S. SætraHaelin KimAnne MarstadSigne E. ÅsbergTrine A. StrandMarkus HaugMichael NiederweisHarald A. StenmarkTrude H. FloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai S. Beckwith Marianne S. Beckwith Sindre Ullmann Ragnhild S. Sætra Haelin Kim Anne Marstad Signe E. Åsberg Trine A. Strand Markus Haug Michael Niederweis Harald A. Stenmark Trude H. Flo Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
description	Inflammasome activation is a response to bacterial infection but can cause damage and spread infection. Here, the authors use live single-cell imaging to show two mechanisms by which M. tuberculosis causes damage to human macrophage cell plasma membranes, resulting in activation of the NLRP3 inflammasome, pyroptosis and release of infectious particles.
format	article
author	Kai S. Beckwith Marianne S. Beckwith Sindre Ullmann Ragnhild S. Sætra Haelin Kim Anne Marstad Signe E. Åsberg Trine A. Strand Markus Haug Michael Niederweis Harald A. Stenmark Trude H. Flo
author_facet	Kai S. Beckwith Marianne S. Beckwith Sindre Ullmann Ragnhild S. Sætra Haelin Kim Anne Marstad Signe E. Åsberg Trine A. Strand Markus Haug Michael Niederweis Harald A. Stenmark Trude H. Flo
author_sort	Kai S. Beckwith
title	Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
title_short	Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
title_full	Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
title_fullStr	Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
title_full_unstemmed	Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
title_sort	plasma membrane damage causes nlrp3 activation and pyroptosis during mycobacterium tuberculosis infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9546bc66dd1e4c0bb737b9ca565a8f54
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Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

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