Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting

Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates...

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Autores principales:	Yiming Zhang, Cassandra B. Higgins, Hannah M. Fortune, Phillip Chen, Alicyn I. Stothard, Allyson L. Mayer, Benjamin M. Swarts, Brian J. DeBosch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/954749bafaf0425d8c21a4c09fdcf947
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spelling	oai:doaj.org-article:954749bafaf0425d8c21a4c09fdcf9472021-12-02T16:57:44ZHepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting10.1038/s41467-019-09642-82041-1723https://doaj.org/article/954749bafaf0425d8c21a4c09fdcf9472019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09642-8https://doaj.org/toc/2041-1723Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates the positive effects of fasting in obesity and diabetes.Yiming ZhangCassandra B. HigginsHannah M. FortunePhillip ChenAlicyn I. StothardAllyson L. MayerBenjamin M. SwartsBrian J. DeBoschNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
description	Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates the positive effects of fasting in obesity and diabetes.
format	article
author	Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch
author_facet	Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch
author_sort	Yiming Zhang
title	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_short	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_full	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_fullStr	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_full_unstemmed	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_sort	hepatic arginase 2 (arg2) is sufficient to convey the therapeutic metabolic effects of fasting
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/954749bafaf0425d8c21a4c09fdcf947
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Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting

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