Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release

Hydrogels chitosan-poly-(N-vinyl-pyrrolidone)-alginate (Ch/PVP/Alg) have been synthesized with Ca2+, Zn2+ and formaldehyde as crosslinker. Hydrogels with ratio polymer 70:20:10 give a high swelling ratio and good network. The Ch/PVP/Alg/Ca2+ has 463.73% swelling ratio and 80.59% gel. Ch/PVP/Alg/Zn h...

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Autores principales:	Kartini Afriani, Tri Sutanti Budikania
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2020
Materias:	chitosan hydrogel poly-(n-vinyl-pyrrolidone) alginate swelling Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9548b5e9d9ad4bdf8ab4eebcf0034c5b
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spelling	oai:doaj.org-article:9548b5e9d9ad4bdf8ab4eebcf0034c5b2021-11-10T07:26:11ZSynthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release2302-46902541-0733https://doaj.org/article/9548b5e9d9ad4bdf8ab4eebcf0034c5b2020-10-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/558/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2541-0733Hydrogels chitosan-poly-(N-vinyl-pyrrolidone)-alginate (Ch/PVP/Alg) have been synthesized with Ca2+, Zn2+ and formaldehyde as crosslinker. Hydrogels with ratio polymer 70:20:10 give a high swelling ratio and good network. The Ch/PVP/Alg/Ca2+ has 463.73% swelling ratio and 80.59% gel. Ch/PVP/Alg/Zn has 489.21% swelling ratio and 81.67% gel. Ch/PVP/Alg crosslinked with formaldehyde result 488.03% swelling ratio and 85.34% gel. Dissolution test of hydrogels in pH 1.2 releases ibuprofen less than 30%. Whereas in the pH 7.4, the release of ibuprofen by hydrogels are relatively high. Ch/PVP/Alg/Ca reach up to 34.63% in 30 minutes and 40.86% for Ch/PVP/Alg/Zn. Meanwhile Ch/PVP/Alg/CH2O can release 44.92% of ibuprofen in 30 minutes. The obtained hydrogel was characterized using infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).Kartini AfrianiTri Sutanti BudikaniaUniversity of Brawijayaarticlechitosanhydrogelpoly-(n-vinyl-pyrrolidone)alginateswellingChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 09, Iss 3, Pp 200-211 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan hydrogel poly-(n-vinyl-pyrrolidone) alginate swelling Chemistry QD1-999
spellingShingle	chitosan hydrogel poly-(n-vinyl-pyrrolidone) alginate swelling Chemistry QD1-999 Kartini Afriani Tri Sutanti Budikania Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release
description	Hydrogels chitosan-poly-(N-vinyl-pyrrolidone)-alginate (Ch/PVP/Alg) have been synthesized with Ca2+, Zn2+ and formaldehyde as crosslinker. Hydrogels with ratio polymer 70:20:10 give a high swelling ratio and good network. The Ch/PVP/Alg/Ca2+ has 463.73% swelling ratio and 80.59% gel. Ch/PVP/Alg/Zn has 489.21% swelling ratio and 81.67% gel. Ch/PVP/Alg crosslinked with formaldehyde result 488.03% swelling ratio and 85.34% gel. Dissolution test of hydrogels in pH 1.2 releases ibuprofen less than 30%. Whereas in the pH 7.4, the release of ibuprofen by hydrogels are relatively high. Ch/PVP/Alg/Ca reach up to 34.63% in 30 minutes and 40.86% for Ch/PVP/Alg/Zn. Meanwhile Ch/PVP/Alg/CH2O can release 44.92% of ibuprofen in 30 minutes. The obtained hydrogel was characterized using infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).
format	article
author	Kartini Afriani Tri Sutanti Budikania
author_facet	Kartini Afriani Tri Sutanti Budikania
author_sort	Kartini Afriani
title	Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release
title_short	Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release
title_full	Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release
title_fullStr	Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release
title_full_unstemmed	Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release
title_sort	synthesis and characterization of hydrogel of chitosan-poly (n-vinyl-2-pirrolidone) (pvp)- alginate for ibuprofen release
publisher	University of Brawijaya
publishDate	2020
url	https://doaj.org/article/9548b5e9d9ad4bdf8ab4eebcf0034c5b
work_keys_str_mv	AT kartiniafriani synthesisandcharacterizationofhydrogelofchitosanpolynvinyl2pirrolidonepvpalginateforibuprofenrelease AT trisutantibudikania synthesisandcharacterizationofhydrogelofchitosanpolynvinyl2pirrolidonepvpalginateforibuprofenrelease
_version_	1718440491840700416

Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release

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