Engineered microbial consortia: strategies and applications

Abstract Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome...

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Autores principales:	Katherine E. Duncker, Zachary A. Holmes, Lingchong You
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/954babc3d04b46968459b52a92c49173
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spelling	oai:doaj.org-article:954babc3d04b46968459b52a92c491732021-11-21T12:40:41ZEngineered microbial consortia: strategies and applications10.1186/s12934-021-01699-91475-2859https://doaj.org/article/954babc3d04b46968459b52a92c491732021-11-01T00:00:00Zhttps://doi.org/10.1186/s12934-021-01699-9https://doaj.org/toc/1475-2859Abstract Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome these limitations, microbial consortia can be engineered to distribute complex tasks among multiple populations. Recent studies have made substantial progress in programming microbial consortia for both basic understanding and potential applications. Microbial consortia have been designed through diverse strategies, including programming mutualistic interactions, using programmed population control to prevent overgrowth of individual populations, and spatial segregation to reduce competition. Here, we highlight the role of microbial consortia in the advances of metabolic engineering, biofilm production for engineered living materials, biocomputing, and biosensing. Additionally, we discuss the challenges for future research in microbial consortia.Katherine E. DunckerZachary A. HolmesLingchong YouBMCarticleMicrobiologyQR1-502ENMicrobial Cell Factories, Vol 20, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Katherine E. Duncker Zachary A. Holmes Lingchong You Engineered microbial consortia: strategies and applications
description	Abstract Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome these limitations, microbial consortia can be engineered to distribute complex tasks among multiple populations. Recent studies have made substantial progress in programming microbial consortia for both basic understanding and potential applications. Microbial consortia have been designed through diverse strategies, including programming mutualistic interactions, using programmed population control to prevent overgrowth of individual populations, and spatial segregation to reduce competition. Here, we highlight the role of microbial consortia in the advances of metabolic engineering, biofilm production for engineered living materials, biocomputing, and biosensing. Additionally, we discuss the challenges for future research in microbial consortia.
format	article
author	Katherine E. Duncker Zachary A. Holmes Lingchong You
author_facet	Katherine E. Duncker Zachary A. Holmes Lingchong You
author_sort	Katherine E. Duncker
title	Engineered microbial consortia: strategies and applications
title_short	Engineered microbial consortia: strategies and applications
title_full	Engineered microbial consortia: strategies and applications
title_fullStr	Engineered microbial consortia: strategies and applications
title_full_unstemmed	Engineered microbial consortia: strategies and applications
title_sort	engineered microbial consortia: strategies and applications
publisher	BMC
publishDate	2021
url	https://doaj.org/article/954babc3d04b46968459b52a92c49173
work_keys_str_mv	AT katherineeduncker engineeredmicrobialconsortiastrategiesandapplications AT zacharyaholmes engineeredmicrobialconsortiastrategiesandapplications AT lingchongyou engineeredmicrobialconsortiastrategiesandapplications
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Engineered microbial consortia: strategies and applications

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