AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

The diabetes drug Metformin decreases hepatic glucose production and activates AMP-activated protein kinase (AMPK). Here the authors provide evidence that AMPK activation antagonizes glucagon signalling by activating PDE4B, lowering cAMP levels and decreasing PKA activation.

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Autores principales:	M. Johanns, Y.-C. Lai, M.-F. Hsu, R. Jacobs, D. Vertommen, J. Van Sande, J. E. Dumont, A. Woods, D. Carling, L. Hue, B. Viollet, M Foretz, M H Rider
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/954bee2fc4df4777831074056e3cfc45
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spelling	oai:doaj.org-article:954bee2fc4df4777831074056e3cfc452021-12-02T16:57:29ZAMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B10.1038/ncomms108562041-1723https://doaj.org/article/954bee2fc4df4777831074056e3cfc452016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10856https://doaj.org/toc/2041-1723The diabetes drug Metformin decreases hepatic glucose production and activates AMP-activated protein kinase (AMPK). Here the authors provide evidence that AMPK activation antagonizes glucagon signalling by activating PDE4B, lowering cAMP levels and decreasing PKA activation.M. JohannsY.-C. LaiM.-F. HsuR. JacobsD. VertommenJ. Van SandeJ. E. DumontA. WoodsD. CarlingL. HueB. ViolletM ForetzM H RiderNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Johanns Y.-C. Lai M.-F. Hsu R. Jacobs D. Vertommen J. Van Sande J. E. Dumont A. Woods D. Carling L. Hue B. Viollet M Foretz M H Rider AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
description	The diabetes drug Metformin decreases hepatic glucose production and activates AMP-activated protein kinase (AMPK). Here the authors provide evidence that AMPK activation antagonizes glucagon signalling by activating PDE4B, lowering cAMP levels and decreasing PKA activation.
format	article
author	M. Johanns Y.-C. Lai M.-F. Hsu R. Jacobs D. Vertommen J. Van Sande J. E. Dumont A. Woods D. Carling L. Hue B. Viollet M Foretz M H Rider
author_facet	M. Johanns Y.-C. Lai M.-F. Hsu R. Jacobs D. Vertommen J. Van Sande J. E. Dumont A. Woods D. Carling L. Hue B. Viollet M Foretz M H Rider
author_sort	M. Johanns
title	AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
title_short	AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
title_full	AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
title_fullStr	AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
title_full_unstemmed	AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
title_sort	ampk antagonizes hepatic glucagon-stimulated cyclic amp signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4b
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/954bee2fc4df4777831074056e3cfc45
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AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

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