Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.

Previous studies have shown that lactate/albumin ratio (LAR) can be used as a prognostic biomarker to independently predict the mortality of sepsis and severe heart failure. However, the role of LAR as an independent prognostic factor in all-cause mortality in patients with acute respiratory failure...

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Autores principales:	Yan Lu, Haoyang Guo, Xuya Chen, Qiaohong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/954c641e368e40fc9d9585467f065d57
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spelling	oai:doaj.org-article:954c641e368e40fc9d9585467f065d572021-12-02T20:19:36ZAssociation between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.1932-620310.1371/journal.pone.0255744https://doaj.org/article/954c641e368e40fc9d9585467f065d572021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255744https://doaj.org/toc/1932-6203Previous studies have shown that lactate/albumin ratio (LAR) can be used as a prognostic biomarker to independently predict the mortality of sepsis and severe heart failure. However, the role of LAR as an independent prognostic factor in all-cause mortality in patients with acute respiratory failure (ARF) remains to be clarified. Therefore, we retrospectively analyzed 2170 patients with ARF in Medical Information Mart for Intensive Care Database III from 2001 to 2012. By drawing the receiver operating characteristic curve, LAR shows a better predictive value in predicting the 30-day mortality of ARF patients (AUC: 0.646), which is higher than that of albumin (AUC: 0.631) or lactate (AUC: 0.616) alone, and even higher than SOFA score(AUC: 0.642). COX regression analysis and Kaplan-Meier curve objectively and intuitively show that high LAR is a risk factor for patients with ARF, which is positively correlated with all-cause mortality. As an easy-to-obtain and objective biomarker, LAR deserves further verification by multi-center prospective studies.Yan LuHaoyang GuoXuya ChenQiaohong ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255744 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Lu Haoyang Guo Xuya Chen Qiaohong Zhang Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.
description	Previous studies have shown that lactate/albumin ratio (LAR) can be used as a prognostic biomarker to independently predict the mortality of sepsis and severe heart failure. However, the role of LAR as an independent prognostic factor in all-cause mortality in patients with acute respiratory failure (ARF) remains to be clarified. Therefore, we retrospectively analyzed 2170 patients with ARF in Medical Information Mart for Intensive Care Database III from 2001 to 2012. By drawing the receiver operating characteristic curve, LAR shows a better predictive value in predicting the 30-day mortality of ARF patients (AUC: 0.646), which is higher than that of albumin (AUC: 0.631) or lactate (AUC: 0.616) alone, and even higher than SOFA score(AUC: 0.642). COX regression analysis and Kaplan-Meier curve objectively and intuitively show that high LAR is a risk factor for patients with ARF, which is positively correlated with all-cause mortality. As an easy-to-obtain and objective biomarker, LAR deserves further verification by multi-center prospective studies.
format	article
author	Yan Lu Haoyang Guo Xuya Chen Qiaohong Zhang
author_facet	Yan Lu Haoyang Guo Xuya Chen Qiaohong Zhang
author_sort	Yan Lu
title	Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.
title_short	Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.
title_full	Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.
title_fullStr	Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.
title_full_unstemmed	Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.
title_sort	association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: a retrospective analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/954c641e368e40fc9d9585467f065d57
work_keys_str_mv	AT yanlu associationbetweenlactatealbuminratioandallcausemortalityinpatientswithacuterespiratoryfailurearetrospectiveanalysis AT haoyangguo associationbetweenlactatealbuminratioandallcausemortalityinpatientswithacuterespiratoryfailurearetrospectiveanalysis AT xuyachen associationbetweenlactatealbuminratioandallcausemortalityinpatientswithacuterespiratoryfailurearetrospectiveanalysis AT qiaohongzhang associationbetweenlactatealbuminratioandallcausemortalityinpatientswithacuterespiratoryfailurearetrospectiveanalysis
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Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.

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