Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.

<h4>Background</h4>Serum concentrations of the tumor-associated folate receptor 1 (FOLR1) protein may be a marker for early cancer detection, yet concentrations have also been detected in cancer-free women. We investigated the conditions associated with circulating FOLR1 protein in healt...

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Autores principales:	Linda E Kelemen, James D Brenton, Christine Parkinson, Hayley C Whitaker, Anna M Piskorz, Ilona Csizmadi, Paula J Robson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/954d4f6ea3f643a8bfcc820be7a0718f
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spelling	oai:doaj.org-article:954d4f6ea3f643a8bfcc820be7a0718f2021-11-18T08:20:09ZConditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.1932-620310.1371/journal.pone.0096542https://doaj.org/article/954d4f6ea3f643a8bfcc820be7a0718f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24810481/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Serum concentrations of the tumor-associated folate receptor 1 (FOLR1) protein may be a marker for early cancer detection, yet concentrations have also been detected in cancer-free women. We investigated the conditions associated with circulating FOLR1 protein in healthy individuals and sought to clarify the range of normal serum values.<h4>Methods</h4>Sera of cancer-free men and women (N = 60) enrolled in a population-based cohort study in Alberta, Canada were analyzed for FOLR1 protein using an electrochemical luminescence immunoassay. Dietary, lifestyle, medical and reproductive history information was collected by questionnaires. Differences in serum FOLR1 concentrations between groups were assessed by non-parametric tests, and predictors of serum FOLR1 concentrations were estimated using multivariable linear regression.<h4>Results</h4>Median serum FOLR1 concentration was higher in women (491 pg/ml, range = 327-693 pg/ml) than in men (404 pg/ml, range = 340-682 pg/ml), P = 0.001. FOLR1 concentration was also positively associated with vitamin A intake (P = 0.02), and showed positive trends with age and with oral contraceptive hormone use among women and an inverse trend with body mass index. All variables examined explained almost half of the variation in serum FOLR1 (model R2 = 0.44, P = 0.04); however, the retention of gender (P = 0.003) and vitamin A intake (P = 0.03) together explained 20% (P = 0.001) of serum FOLR1 variation. No other predictor was significant at P<0.05.<h4>Conclusions</h4>The positive association between serum FOLR1 concentration and female gender independent of an age effect suggests caution against statements to exploit serum FOLR1 for early cancer detection without further understanding the biological underpinnings of these observations. Serum FOLR1 concentrations may be influenced by the steroid retinoic acid (vitamin A) but do not appear to be associated with folate nutritional status. These findings require confirmation in larger independent studies.Linda E KelemenJames D BrentonChristine ParkinsonHayley C WhitakerAnna M PiskorzIlona CsizmadiPaula J RobsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96542 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linda E Kelemen James D Brenton Christine Parkinson Hayley C Whitaker Anna M Piskorz Ilona Csizmadi Paula J Robson Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
description	<h4>Background</h4>Serum concentrations of the tumor-associated folate receptor 1 (FOLR1) protein may be a marker for early cancer detection, yet concentrations have also been detected in cancer-free women. We investigated the conditions associated with circulating FOLR1 protein in healthy individuals and sought to clarify the range of normal serum values.<h4>Methods</h4>Sera of cancer-free men and women (N = 60) enrolled in a population-based cohort study in Alberta, Canada were analyzed for FOLR1 protein using an electrochemical luminescence immunoassay. Dietary, lifestyle, medical and reproductive history information was collected by questionnaires. Differences in serum FOLR1 concentrations between groups were assessed by non-parametric tests, and predictors of serum FOLR1 concentrations were estimated using multivariable linear regression.<h4>Results</h4>Median serum FOLR1 concentration was higher in women (491 pg/ml, range = 327-693 pg/ml) than in men (404 pg/ml, range = 340-682 pg/ml), P = 0.001. FOLR1 concentration was also positively associated with vitamin A intake (P = 0.02), and showed positive trends with age and with oral contraceptive hormone use among women and an inverse trend with body mass index. All variables examined explained almost half of the variation in serum FOLR1 (model R2 = 0.44, P = 0.04); however, the retention of gender (P = 0.003) and vitamin A intake (P = 0.03) together explained 20% (P = 0.001) of serum FOLR1 variation. No other predictor was significant at P<0.05.<h4>Conclusions</h4>The positive association between serum FOLR1 concentration and female gender independent of an age effect suggests caution against statements to exploit serum FOLR1 for early cancer detection without further understanding the biological underpinnings of these observations. Serum FOLR1 concentrations may be influenced by the steroid retinoic acid (vitamin A) but do not appear to be associated with folate nutritional status. These findings require confirmation in larger independent studies.
format	article
author	Linda E Kelemen James D Brenton Christine Parkinson Hayley C Whitaker Anna M Piskorz Ilona Csizmadi Paula J Robson
author_facet	Linda E Kelemen James D Brenton Christine Parkinson Hayley C Whitaker Anna M Piskorz Ilona Csizmadi Paula J Robson
author_sort	Linda E Kelemen
title	Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
title_short	Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
title_full	Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
title_fullStr	Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
title_full_unstemmed	Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
title_sort	conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/954d4f6ea3f643a8bfcc820be7a0718f
work_keys_str_mv	AT lindaekelemen conditionsassociatedwithcirculatingtumorassociatedfolatereceptor1proteininhealthymenandwomen AT jamesdbrenton conditionsassociatedwithcirculatingtumorassociatedfolatereceptor1proteininhealthymenandwomen AT christineparkinson conditionsassociatedwithcirculatingtumorassociatedfolatereceptor1proteininhealthymenandwomen AT hayleycwhitaker conditionsassociatedwithcirculatingtumorassociatedfolatereceptor1proteininhealthymenandwomen AT annampiskorz conditionsassociatedwithcirculatingtumorassociatedfolatereceptor1proteininhealthymenandwomen AT ilonacsizmadi conditionsassociatedwithcirculatingtumorassociatedfolatereceptor1proteininhealthymenandwomen AT paulajrobson conditionsassociatedwithcirculatingtumorassociatedfolatereceptor1proteininhealthymenandwomen
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Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.

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