Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line

Susan Azizi,1 Mahnaz Mahdavi Shahri,2 Heshu Sulaiman Rahman,3–5 Raha Abdul Rahim,6 Abdullah Rasedee,5 Rosfarizan Mohamad1,7 1Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia; 2Department of...

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Autores principales:	Azizi S, Mahdavi Shahri M, Rahman HS, Rahim RA, Rasedee A, Mohamad R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	green synthesis Palladium nanoparticles White tea MOLT-4 cells cytotoxicity antibacterial activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/954f6615237e49d1891c18284c437fa2
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spelling	oai:doaj.org-article:954f6615237e49d1891c18284c437fa22021-12-02T05:40:29ZGreen synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line1178-2013https://doaj.org/article/954f6615237e49d1891c18284c437fa22017-12-01T00:00:00Zhttps://www.dovepress.com/green-synthesis-palladium-nanoparticles-mediated-by-white-tea-camellia-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Susan Azizi,1 Mahnaz Mahdavi Shahri,2 Heshu Sulaiman Rahman,3–5 Raha Abdul Rahim,6 Abdullah Rasedee,5 Rosfarizan Mohamad1,7 1Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia; 2Department of Chemistry, Shiraz Branch, Islamic Azad University, Shiraz, Iran; 3College of Veterinary Medicine, University of Sulaimani, Sulaimani Nwe, 4College of Health Science, Komar University of Science and Technology (KUST), Chaq-Chaq Qularaise, Sulaimani City, Iraq; 5Faculty of Veterinary Medicine, 6Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, 7Laboratory of Biopolymer and Derivatives, Institute of Tropical Forestry and Forest Products, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia Abstract: Among nanoparticles used for medical applications, palladium nanoparticles (PdNPs) are among the least investigated. This study was undertaken to develop PdNPs by green synthesis using white tea (W.tea; Camellia sinensis) extract to produce the Pd@W.tea NPs. The Pd@W.tea NPs were characterized by UV–vis spectroscopy and X-ray diffractometry, and evaluated with transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The Pd@W.tea NPs were spherical (size 6–18 nm) and contained phenols and flavonoids acquired from the W.tea extract. Pd@W.tea NPs has good 1-diphenyl-2-picrylhydrazyl (DPPH), OH, and NO-scavenging properties as well as antibacterial effects toward Staphylococcus epidermidis and Escherichia coli. MTT assay showed that Pd@W.tea NPs (IC50 =0.006 µM) were more antiproliferative toward the human leukemia (MOLT-4) cells than the W.tea extract (IC50 =0.894 µM), doxorubicin (IC50 =2.133 µM), or cisplatin (IC50 =0.013 µM), whereas they were relatively innocuous for normal human fibroblast (HDF-a) cells. The anticancer cell effects of Pd@W.tea NPs are mediated through the induction of apoptosis and G2/M cell-cycle arrest. Keywords: green synthesis, palladium nanoparticles, white tea, leukemic cells, cytotoxicity, medical application, nanobiotechnologyAzizi SMahdavi Shahri MRahman HSRahim RARasedee AMohamad RDove Medical Pressarticlegreen synthesisPalladium nanoparticlesWhite teaMOLT-4 cellscytotoxicityantibacterial activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8841-8853 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	green synthesis Palladium nanoparticles White tea MOLT-4 cells cytotoxicity antibacterial activity Medicine (General) R5-920
spellingShingle	green synthesis Palladium nanoparticles White tea MOLT-4 cells cytotoxicity antibacterial activity Medicine (General) R5-920 Azizi S Mahdavi Shahri M Rahman HS Rahim RA Rasedee A Mohamad R Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
description	Susan Azizi,1 Mahnaz Mahdavi Shahri,2 Heshu Sulaiman Rahman,3–5 Raha Abdul Rahim,6 Abdullah Rasedee,5 Rosfarizan Mohamad1,7 1Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia; 2Department of Chemistry, Shiraz Branch, Islamic Azad University, Shiraz, Iran; 3College of Veterinary Medicine, University of Sulaimani, Sulaimani Nwe, 4College of Health Science, Komar University of Science and Technology (KUST), Chaq-Chaq Qularaise, Sulaimani City, Iraq; 5Faculty of Veterinary Medicine, 6Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, 7Laboratory of Biopolymer and Derivatives, Institute of Tropical Forestry and Forest Products, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia Abstract: Among nanoparticles used for medical applications, palladium nanoparticles (PdNPs) are among the least investigated. This study was undertaken to develop PdNPs by green synthesis using white tea (W.tea; Camellia sinensis) extract to produce the Pd@W.tea NPs. The Pd@W.tea NPs were characterized by UV–vis spectroscopy and X-ray diffractometry, and evaluated with transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The Pd@W.tea NPs were spherical (size 6–18 nm) and contained phenols and flavonoids acquired from the W.tea extract. Pd@W.tea NPs has good 1-diphenyl-2-picrylhydrazyl (DPPH), OH, and NO-scavenging properties as well as antibacterial effects toward Staphylococcus epidermidis and Escherichia coli. MTT assay showed that Pd@W.tea NPs (IC50 =0.006 µM) were more antiproliferative toward the human leukemia (MOLT-4) cells than the W.tea extract (IC50 =0.894 µM), doxorubicin (IC50 =2.133 µM), or cisplatin (IC50 =0.013 µM), whereas they were relatively innocuous for normal human fibroblast (HDF-a) cells. The anticancer cell effects of Pd@W.tea NPs are mediated through the induction of apoptosis and G2/M cell-cycle arrest. Keywords: green synthesis, palladium nanoparticles, white tea, leukemic cells, cytotoxicity, medical application, nanobiotechnology
format	article
author	Azizi S Mahdavi Shahri M Rahman HS Rahim RA Rasedee A Mohamad R
author_facet	Azizi S Mahdavi Shahri M Rahman HS Rahim RA Rasedee A Mohamad R
author_sort	Azizi S
title	Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
title_short	Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
title_full	Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
title_fullStr	Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
title_full_unstemmed	Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
title_sort	green synthesis palladium nanoparticles mediated by white tea (camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (molt-4) cell line
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/954f6615237e49d1891c18284c437fa2
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Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line

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