A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery

Abstract There is still no established therapeutic solution for postoperative Dry Eye Syndrome (DES) after cataract surgery, in spite of progress in surgical techniques. Diquafosol tetrasodium (DQS), a recently developed ophthalmic solution, has been reported to be effective in DES, but no study eva...

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Autores principales:	Sangyoon Kim, Jonghoon Shin, Ji Eun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9557fd5aa3fe47c69d9dfc56eea9da3a
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spelling	oai:doaj.org-article:9557fd5aa3fe47c69d9dfc56eea9da3a2021-12-02T13:41:23ZA randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery10.1038/s41598-021-88589-72045-2322https://doaj.org/article/9557fd5aa3fe47c69d9dfc56eea9da3a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88589-7https://doaj.org/toc/2045-2322Abstract There is still no established therapeutic solution for postoperative Dry Eye Syndrome (DES) after cataract surgery, in spite of progress in surgical techniques. Diquafosol tetrasodium (DQS), a recently developed ophthalmic solution, has been reported to be effective in DES, but no study evaluated post-cataract surgery lipid layer thickness (LLT) changes in healthy patients who used DQS postoperatively. We randomly divided participants into two groups; the DQS group was treated six times daily with DQS after cataract surgery, and the sodium hyaluronate (HA) group was treated with HA in the same way. Throughout study period, the DQS group showed significantly higher tear break up time (TBUT) and LLT than HA group. In multivariate analysis, better preoperative TBUT, Schirmer’s I test score, ocular surface disease index (OSDI) score, and LLT were significantly associated with improved postoperative outcomes in each parameter. Also, the postoperative use of DQS served as an independent parameter of better TBUT, OSDI score, and LLT in postoperative 15 weeks. Treatment with 3% DQS following cataract surgery showed more improvement in TBUT and LLT, compared with 0.1% HA. Improving TBUT and LLT preoperatively and using 3% DQS postoperatively, could be a reliable choice for managing DES after cataract surgery. Trial Registration: ISRCTN registry with ISRCTN 18755487.Sangyoon KimJonghoon ShinJi Eun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sangyoon Kim Jonghoon Shin Ji Eun Lee A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery
description	Abstract There is still no established therapeutic solution for postoperative Dry Eye Syndrome (DES) after cataract surgery, in spite of progress in surgical techniques. Diquafosol tetrasodium (DQS), a recently developed ophthalmic solution, has been reported to be effective in DES, but no study evaluated post-cataract surgery lipid layer thickness (LLT) changes in healthy patients who used DQS postoperatively. We randomly divided participants into two groups; the DQS group was treated six times daily with DQS after cataract surgery, and the sodium hyaluronate (HA) group was treated with HA in the same way. Throughout study period, the DQS group showed significantly higher tear break up time (TBUT) and LLT than HA group. In multivariate analysis, better preoperative TBUT, Schirmer’s I test score, ocular surface disease index (OSDI) score, and LLT were significantly associated with improved postoperative outcomes in each parameter. Also, the postoperative use of DQS served as an independent parameter of better TBUT, OSDI score, and LLT in postoperative 15 weeks. Treatment with 3% DQS following cataract surgery showed more improvement in TBUT and LLT, compared with 0.1% HA. Improving TBUT and LLT preoperatively and using 3% DQS postoperatively, could be a reliable choice for managing DES after cataract surgery. Trial Registration: ISRCTN registry with ISRCTN 18755487.
format	article
author	Sangyoon Kim Jonghoon Shin Ji Eun Lee
author_facet	Sangyoon Kim Jonghoon Shin Ji Eun Lee
author_sort	Sangyoon Kim
title	A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery
title_short	A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery
title_full	A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery
title_fullStr	A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery
title_full_unstemmed	A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery
title_sort	randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9557fd5aa3fe47c69d9dfc56eea9da3a
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A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery

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