Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance

Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance

Type 2 diabetes is associated with chronic inflammation and is characterized by insulin resistance. Here, the authors identify a crucial role for endothelial BMPER function in glucose homeostasis, and BMPER overexpression was shown to alleviate insulin resistance and hyperglycemia in diabetic mice.

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Autores principales: Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Huaizhu Wu, Christie M. Ballantyne, Sean M. Hartig, Liang Xie, Xinchun Pi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/955957e083474c468a00c6e9258ec4a1
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spelling oai:doaj.org-article:955957e083474c468a00c6e9258ec4a12021-12-02T13:24:23ZLoss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance10.1038/s41467-021-22130-22041-1723https://doaj.org/article/955957e083474c468a00c6e9258ec4a12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22130-2https://doaj.org/toc/2041-1723Type 2 diabetes is associated with chronic inflammation and is characterized by insulin resistance. Here, the authors identify a crucial role for endothelial BMPER function in glucose homeostasis, and BMPER overexpression was shown to alleviate insulin resistance and hyperglycemia in diabetic mice.Hua MaoLuge LiQiying FanAude AngeliniPradip K. SahaHuaizhu WuChristie M. BallantyneSean M. HartigLiang XieXinchun PiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hua Mao
Luge Li
Qiying Fan
Aude Angelini
Pradip K. Saha
Huaizhu Wu
Christie M. Ballantyne
Sean M. Hartig
Liang Xie
Xinchun Pi
Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
description Type 2 diabetes is associated with chronic inflammation and is characterized by insulin resistance. Here, the authors identify a crucial role for endothelial BMPER function in glucose homeostasis, and BMPER overexpression was shown to alleviate insulin resistance and hyperglycemia in diabetic mice.
format article
author Hua Mao
Luge Li
Qiying Fan
Aude Angelini
Pradip K. Saha
Huaizhu Wu
Christie M. Ballantyne
Sean M. Hartig
Liang Xie
Xinchun Pi
author_facet Hua Mao
Luge Li
Qiying Fan
Aude Angelini
Pradip K. Saha
Huaizhu Wu
Christie M. Ballantyne
Sean M. Hartig
Liang Xie
Xinchun Pi
author_sort Hua Mao
title Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
title_short Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
title_full Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
title_fullStr Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
title_full_unstemmed Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
title_sort loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/955957e083474c468a00c6e9258ec4a1
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AT audeangelini lossofbonemorphogeneticproteinbindingendothelialregulatorcausesinsulinresistance
AT pradipksaha lossofbonemorphogeneticproteinbindingendothelialregulatorcausesinsulinresistance
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AT seanmhartig lossofbonemorphogeneticproteinbindingendothelialregulatorcausesinsulinresistance
AT liangxie lossofbonemorphogeneticproteinbindingendothelialregulatorcausesinsulinresistance
AT xinchunpi lossofbonemorphogeneticproteinbindingendothelialregulatorcausesinsulinresistance
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