The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation
Excessive inflammation can be tissue destructive and contributes to auotinflammatory diseases and sepsis pathology. Here the authors show that the lncRNA Mirt2 is an endogenous negative feedback regulator of LPS-induced inflammation by limiting ubiquitination of TRAF6 and NF-κB activation.
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/9559c18bd2b8412bb18a884595349028 |
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oai:doaj.org-article:9559c18bd2b8412bb18a8845953490282021-12-02T15:38:51ZThe LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation10.1038/s41467-017-02229-12041-1723https://doaj.org/article/9559c18bd2b8412bb18a8845953490282017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02229-1https://doaj.org/toc/2041-1723Excessive inflammation can be tissue destructive and contributes to auotinflammatory diseases and sepsis pathology. Here the authors show that the lncRNA Mirt2 is an endogenous negative feedback regulator of LPS-induced inflammation by limiting ubiquitination of TRAF6 and NF-κB activation.Meng DuLin YuanXin TanDandan HuangXiaojing WangZhe ZhengXiaoxiang MaoXiangrao LiLiu YangKun HuangFengxiao ZhangYan WangXi LuoDan HuangKai HuangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Meng Du Lin Yuan Xin Tan Dandan Huang Xiaojing Wang Zhe Zheng Xiaoxiang Mao Xiangrao Li Liu Yang Kun Huang Fengxiao Zhang Yan Wang Xi Luo Dan Huang Kai Huang The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation |
| description |
Excessive inflammation can be tissue destructive and contributes to auotinflammatory diseases and sepsis pathology. Here the authors show that the lncRNA Mirt2 is an endogenous negative feedback regulator of LPS-induced inflammation by limiting ubiquitination of TRAF6 and NF-κB activation. |
| format |
article |
| author |
Meng Du Lin Yuan Xin Tan Dandan Huang Xiaojing Wang Zhe Zheng Xiaoxiang Mao Xiangrao Li Liu Yang Kun Huang Fengxiao Zhang Yan Wang Xi Luo Dan Huang Kai Huang |
| author_facet |
Meng Du Lin Yuan Xin Tan Dandan Huang Xiaojing Wang Zhe Zheng Xiaoxiang Mao Xiangrao Li Liu Yang Kun Huang Fengxiao Zhang Yan Wang Xi Luo Dan Huang Kai Huang |
| author_sort |
Meng Du |
| title |
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation |
| title_short |
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation |
| title_full |
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation |
| title_fullStr |
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation |
| title_full_unstemmed |
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation |
| title_sort |
lps-inducible lncrna mirt2 is a negative regulator of inflammation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/9559c18bd2b8412bb18a884595349028 |
| work_keys_str_mv |
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