MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis

Abstract The aim of this study was to systematically review articles that investigated the prognostic significance of different microRNAs in bladder cancer (BC). We systematically searched PubMed, Web of Science, and Embase to identify relevant studies until March 2016. After screening, 26 studies t...

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Autores principales:	Yongpeng Xie, Xin Ma, Luyao Chen, Hongzhao Li, Liangyou Gu, Yu Gao, Yu Zhang, Xintao Li, Yang Fan, Jianwen Chen, Xu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9559e95d36a84e0e9c07091901a4d9fe
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spelling	oai:doaj.org-article:9559e95d36a84e0e9c07091901a4d9fe2021-12-02T15:06:26ZMicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis10.1038/s41598-017-05801-32045-2322https://doaj.org/article/9559e95d36a84e0e9c07091901a4d9fe2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05801-3https://doaj.org/toc/2045-2322Abstract The aim of this study was to systematically review articles that investigated the prognostic significance of different microRNAs in bladder cancer (BC). We systematically searched PubMed, Web of Science, and Embase to identify relevant studies until March 2016. After screening, 26 studies that involved 2753 patients were included. Results suggested that many miRs expression aberration may predict prognosis in patients with BC. There are six miRs (miR-21, miR-143, miR-155, miR-200, miR-214, and miR-222) were reported by at least two studies, and we performed meta-analysis in the corresponding studies. Accordingly, we found that high miR-21 expression was associated with poor overall survival [OS; hazard ratio (HR) = 3.94, 95% CI 2.08–7.44]. High miR-143 expression was associated with poor progression-free survival (PFS; HR = 3.78, 95% CI 1.61–8.89). High miR-155 expression was associated with poor PFS (HR = 8.10, 95% CI 2.92–22.48). High miR-222 expression was associated with poor OS (HR = 3.39, 95% CI 1.10–10.41). Meanwhile, low miR-214 expression was correlated with poor RFS(HR = 0.34, 95% CI 0.22–0.53). Our comprehensive systematic review concluded that microRNAs, particularly miR-21, miR-143, miR-155, miR-214, and miR-222, could serve as meticulous follow-up markers for early detection of progression or recurrence and even useful therapeutic targets for the treatment in patients with BC.Yongpeng XieXin MaLuyao ChenHongzhao LiLiangyou GuYu GaoYu ZhangXintao LiYang FanJianwen ChenXu ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yongpeng Xie Xin Ma Luyao Chen Hongzhao Li Liangyou Gu Yu Gao Yu Zhang Xintao Li Yang Fan Jianwen Chen Xu Zhang MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis
description	Abstract The aim of this study was to systematically review articles that investigated the prognostic significance of different microRNAs in bladder cancer (BC). We systematically searched PubMed, Web of Science, and Embase to identify relevant studies until March 2016. After screening, 26 studies that involved 2753 patients were included. Results suggested that many miRs expression aberration may predict prognosis in patients with BC. There are six miRs (miR-21, miR-143, miR-155, miR-200, miR-214, and miR-222) were reported by at least two studies, and we performed meta-analysis in the corresponding studies. Accordingly, we found that high miR-21 expression was associated with poor overall survival [OS; hazard ratio (HR) = 3.94, 95% CI 2.08–7.44]. High miR-143 expression was associated with poor progression-free survival (PFS; HR = 3.78, 95% CI 1.61–8.89). High miR-155 expression was associated with poor PFS (HR = 8.10, 95% CI 2.92–22.48). High miR-222 expression was associated with poor OS (HR = 3.39, 95% CI 1.10–10.41). Meanwhile, low miR-214 expression was correlated with poor RFS(HR = 0.34, 95% CI 0.22–0.53). Our comprehensive systematic review concluded that microRNAs, particularly miR-21, miR-143, miR-155, miR-214, and miR-222, could serve as meticulous follow-up markers for early detection of progression or recurrence and even useful therapeutic targets for the treatment in patients with BC.
format	article
author	Yongpeng Xie Xin Ma Luyao Chen Hongzhao Li Liangyou Gu Yu Gao Yu Zhang Xintao Li Yang Fan Jianwen Chen Xu Zhang
author_facet	Yongpeng Xie Xin Ma Luyao Chen Hongzhao Li Liangyou Gu Yu Gao Yu Zhang Xintao Li Yang Fan Jianwen Chen Xu Zhang
author_sort	Yongpeng Xie
title	MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis
title_short	MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis
title_full	MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis
title_fullStr	MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis
title_full_unstemmed	MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis
title_sort	micrornas with prognostic significance in bladder cancer: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9559e95d36a84e0e9c07091901a4d9fe
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MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis

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