LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade

Dynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in pre...

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Autores principales:	Yi Liu, Brian Debo, Mingfeng Li, Zhennan Shi, Wanqiang Sheng, Yang Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/955b0af54ffd473f80b420733cf001e9
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id	oai:doaj.org-article:955b0af54ffd473f80b420733cf001e9
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spelling	oai:doaj.org-article:955b0af54ffd473f80b420733cf001e92021-11-28T12:35:28ZLSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade10.1038/s41467-021-27179-72041-1723https://doaj.org/article/955b0af54ffd473f80b420733cf001e92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27179-7https://doaj.org/toc/2041-1723Dynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in preclinical cancer models.Yi LiuBrian DeboMingfeng LiZhennan ShiWanqiang ShengYang ShiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Liu Brian Debo Mingfeng Li Zhennan Shi Wanqiang Sheng Yang Shi LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
description	Dynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in preclinical cancer models.
format	article
author	Yi Liu Brian Debo Mingfeng Li Zhennan Shi Wanqiang Sheng Yang Shi
author_facet	Yi Liu Brian Debo Mingfeng Li Zhennan Shi Wanqiang Sheng Yang Shi
author_sort	Yi Liu
title	LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
title_short	LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
title_full	LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
title_fullStr	LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
title_full_unstemmed	LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
title_sort	lsd1 inhibition sustains t cell invigoration with a durable response to pd-1 blockade
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/955b0af54ffd473f80b420733cf001e9
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LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade

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