LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade

LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade

Dynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in pre...

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Autores principales: Yi Liu, Brian Debo, Mingfeng Li, Zhennan Shi, Wanqiang Sheng, Yang Shi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/955b0af54ffd473f80b420733cf001e9
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