Cellular mechano-environment regulates the mammary circadian clock

Circadian clocks regulate physiological and behavioural rhythms. Here, the authors show that the stiffness of the extracellular environment regulates circadian clocks in murine breast epithelium via Rho signalling, and explain how extracellular matrix stiffening in aging affects circadian rhythm, wi...

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Autores principales:	Nan Yang, Jack Williams, Vanja Pekovic-Vaughan, Pengbo Wang, Safiah Olabi, James McConnell, Nicole Gossan, Alun Hughes, Julia Cheung, Charles H. Streuli, Qing-Jun Meng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/955c28cf7ce343ed863b7a61fa3f8152
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spelling	oai:doaj.org-article:955c28cf7ce343ed863b7a61fa3f81522021-12-02T14:40:25ZCellular mechano-environment regulates the mammary circadian clock10.1038/ncomms142872041-1723https://doaj.org/article/955c28cf7ce343ed863b7a61fa3f81522017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14287https://doaj.org/toc/2041-1723Circadian clocks regulate physiological and behavioural rhythms. Here, the authors show that the stiffness of the extracellular environment regulates circadian clocks in murine breast epithelium via Rho signalling, and explain how extracellular matrix stiffening in aging affects circadian rhythm, with implication in disease.Nan YangJack WilliamsVanja Pekovic-VaughanPengbo WangSafiah OlabiJames McConnellNicole GossanAlun HughesJulia CheungCharles H. StreuliQing-Jun MengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nan Yang Jack Williams Vanja Pekovic-Vaughan Pengbo Wang Safiah Olabi James McConnell Nicole Gossan Alun Hughes Julia Cheung Charles H. Streuli Qing-Jun Meng Cellular mechano-environment regulates the mammary circadian clock
description	Circadian clocks regulate physiological and behavioural rhythms. Here, the authors show that the stiffness of the extracellular environment regulates circadian clocks in murine breast epithelium via Rho signalling, and explain how extracellular matrix stiffening in aging affects circadian rhythm, with implication in disease.
format	article
author	Nan Yang Jack Williams Vanja Pekovic-Vaughan Pengbo Wang Safiah Olabi James McConnell Nicole Gossan Alun Hughes Julia Cheung Charles H. Streuli Qing-Jun Meng
author_facet	Nan Yang Jack Williams Vanja Pekovic-Vaughan Pengbo Wang Safiah Olabi James McConnell Nicole Gossan Alun Hughes Julia Cheung Charles H. Streuli Qing-Jun Meng
author_sort	Nan Yang
title	Cellular mechano-environment regulates the mammary circadian clock
title_short	Cellular mechano-environment regulates the mammary circadian clock
title_full	Cellular mechano-environment regulates the mammary circadian clock
title_fullStr	Cellular mechano-environment regulates the mammary circadian clock
title_full_unstemmed	Cellular mechano-environment regulates the mammary circadian clock
title_sort	cellular mechano-environment regulates the mammary circadian clock
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/955c28cf7ce343ed863b7a61fa3f8152
work_keys_str_mv	AT nanyang cellularmechanoenvironmentregulatesthemammarycircadianclock AT jackwilliams cellularmechanoenvironmentregulatesthemammarycircadianclock AT vanjapekovicvaughan cellularmechanoenvironmentregulatesthemammarycircadianclock AT pengbowang cellularmechanoenvironmentregulatesthemammarycircadianclock AT safiaholabi cellularmechanoenvironmentregulatesthemammarycircadianclock AT jamesmcconnell cellularmechanoenvironmentregulatesthemammarycircadianclock AT nicolegossan cellularmechanoenvironmentregulatesthemammarycircadianclock AT alunhughes cellularmechanoenvironmentregulatesthemammarycircadianclock AT juliacheung cellularmechanoenvironmentregulatesthemammarycircadianclock AT charleshstreuli cellularmechanoenvironmentregulatesthemammarycircadianclock AT qingjunmeng cellularmechanoenvironmentregulatesthemammarycircadianclock
_version_	1718390310852100096

Cellular mechano-environment regulates the mammary circadian clock

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