Single-molecule kinetics of pore assembly by the membrane attack complex

The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to identify the kinetic bottleneck of MAC formati...

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Auteurs principaux:	Edward S. Parsons, George J. Stanley, Alice L. B. Pyne, Adrian W. Hodel, Adrian P. Nievergelt, Anaïs Menny, Alexander R. Yon, Ashlea Rowley, Ralf P. Richter, Georg E. Fantner, Doryen Bubeck, Bart W. Hoogenboom
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/955c38fbccc64cbdab72da9dedd16f6d
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spelling	oai:doaj.org-article:955c38fbccc64cbdab72da9dedd16f6d2021-12-02T16:57:42ZSingle-molecule kinetics of pore assembly by the membrane attack complex10.1038/s41467-019-10058-72041-1723https://doaj.org/article/955c38fbccc64cbdab72da9dedd16f6d2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10058-7https://doaj.org/toc/2041-1723The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to identify the kinetic bottleneck of MAC formation.Edward S. ParsonsGeorge J. StanleyAlice L. B. PyneAdrian W. HodelAdrian P. NievergeltAnaïs MennyAlexander R. YonAshlea RowleyRalf P. RichterGeorg E. FantnerDoryen BubeckBart W. HoogenboomNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edward S. Parsons George J. Stanley Alice L. B. Pyne Adrian W. Hodel Adrian P. Nievergelt Anaïs Menny Alexander R. Yon Ashlea Rowley Ralf P. Richter Georg E. Fantner Doryen Bubeck Bart W. Hoogenboom Single-molecule kinetics of pore assembly by the membrane attack complex
description	The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to identify the kinetic bottleneck of MAC formation.
format	article
author	Edward S. Parsons George J. Stanley Alice L. B. Pyne Adrian W. Hodel Adrian P. Nievergelt Anaïs Menny Alexander R. Yon Ashlea Rowley Ralf P. Richter Georg E. Fantner Doryen Bubeck Bart W. Hoogenboom
author_facet	Edward S. Parsons George J. Stanley Alice L. B. Pyne Adrian W. Hodel Adrian P. Nievergelt Anaïs Menny Alexander R. Yon Ashlea Rowley Ralf P. Richter Georg E. Fantner Doryen Bubeck Bart W. Hoogenboom
author_sort	Edward S. Parsons
title	Single-molecule kinetics of pore assembly by the membrane attack complex
title_short	Single-molecule kinetics of pore assembly by the membrane attack complex
title_full	Single-molecule kinetics of pore assembly by the membrane attack complex
title_fullStr	Single-molecule kinetics of pore assembly by the membrane attack complex
title_full_unstemmed	Single-molecule kinetics of pore assembly by the membrane attack complex
title_sort	single-molecule kinetics of pore assembly by the membrane attack complex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/955c38fbccc64cbdab72da9dedd16f6d
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Single-molecule kinetics of pore assembly by the membrane attack complex

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