In(s) and out(s) of adolescent depression – Trajectories of development and recovery

While the role of biological markers in understanding major depressive disorder (MDD) in adults have been studied extensively, less has been done to identify the biomarkers of MDD development and recovery in adolescence. With the majority of mental health disorders starting in adolescence, identifyi...

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Autor principal:	Zuzanna Zajkowska
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Adolescent depression Youth Depression Cortisol HPA axis Inflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/955e7c1c33a14e43a890d85222ec2529
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spelling	oai:doaj.org-article:955e7c1c33a14e43a890d85222ec25292021-11-10T04:41:34ZIn(s) and out(s) of adolescent depression – Trajectories of development and recovery2666-354610.1016/j.bbih.2021.100382https://doaj.org/article/955e7c1c33a14e43a890d85222ec25292021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266635462100185Xhttps://doaj.org/toc/2666-3546While the role of biological markers in understanding major depressive disorder (MDD) in adults have been studied extensively, less has been done to identify the biomarkers of MDD development and recovery in adolescence. With the majority of mental health disorders starting in adolescence, identifying biomarkers of transition and recovery from MDD early in life is critical for developing effective prevention strategies. Considering most of the child and adolescent populations come from low-and-middle-income countries (LMICs), it is vital to focus on adolescent populations in these settings. With most studies coming from high-income countries (HICs), evidence suggests that elevated morning cortisol levels including cortisol awakening response (CAR), increased peripheral inflammation and brain abnormalities such as cortico-limbic dysregulation or blunted activity in reward related regions in response to positive information are associated with MDD and being at-risk for MDD development in adolescence. We also find that some of the biological mechanisms of recovery from MDD, mainly normalisation in the cortico-limbic dysregulation, are reported following psychological therapy, suggesting shared pathways leading to MDD vulnerability and recovery. Although, only a few studies include adolescent populations. Understanding molecular mechanisms through which psychological interventions are effective, as well as molecular markers of transition to depression in individuals at-risk, are important to inform effective prevention and intervention strategies.Zuzanna ZajkowskaElsevierarticleAdolescent depressionYouthDepressionCortisolHPA axisInflammationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain, Behavior, & Immunity - Health, Vol 18, Iss , Pp 100382- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adolescent depression Youth Depression Cortisol HPA axis Inflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Adolescent depression Youth Depression Cortisol HPA axis Inflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Zuzanna Zajkowska In(s) and out(s) of adolescent depression – Trajectories of development and recovery
description	While the role of biological markers in understanding major depressive disorder (MDD) in adults have been studied extensively, less has been done to identify the biomarkers of MDD development and recovery in adolescence. With the majority of mental health disorders starting in adolescence, identifying biomarkers of transition and recovery from MDD early in life is critical for developing effective prevention strategies. Considering most of the child and adolescent populations come from low-and-middle-income countries (LMICs), it is vital to focus on adolescent populations in these settings. With most studies coming from high-income countries (HICs), evidence suggests that elevated morning cortisol levels including cortisol awakening response (CAR), increased peripheral inflammation and brain abnormalities such as cortico-limbic dysregulation or blunted activity in reward related regions in response to positive information are associated with MDD and being at-risk for MDD development in adolescence. We also find that some of the biological mechanisms of recovery from MDD, mainly normalisation in the cortico-limbic dysregulation, are reported following psychological therapy, suggesting shared pathways leading to MDD vulnerability and recovery. Although, only a few studies include adolescent populations. Understanding molecular mechanisms through which psychological interventions are effective, as well as molecular markers of transition to depression in individuals at-risk, are important to inform effective prevention and intervention strategies.
format	article
author	Zuzanna Zajkowska
author_facet	Zuzanna Zajkowska
author_sort	Zuzanna Zajkowska
title	In(s) and out(s) of adolescent depression – Trajectories of development and recovery
title_short	In(s) and out(s) of adolescent depression – Trajectories of development and recovery
title_full	In(s) and out(s) of adolescent depression – Trajectories of development and recovery
title_fullStr	In(s) and out(s) of adolescent depression – Trajectories of development and recovery
title_full_unstemmed	In(s) and out(s) of adolescent depression – Trajectories of development and recovery
title_sort	in(s) and out(s) of adolescent depression – trajectories of development and recovery
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/955e7c1c33a14e43a890d85222ec2529
work_keys_str_mv	AT zuzannazajkowska insandoutsofadolescentdepressiontrajectoriesofdevelopmentandrecovery
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In(s) and out(s) of adolescent depression – Trajectories of development and recovery

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