Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

The post-transcriptional 5-methylcytosine (m5C) modification occurs in a wide range of nuclear-encoded RNAs. Here the authors identify the mitochondrial tRNA-Met as a target for the m5C methyltransferase NSun3—found mutated in a mitochondrial disease patient—and link mitochondrial tRNA modifications...

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Autores principales:	Lindsey Van Haute, Sabine Dietmann, Laura Kremer, Shobbir Hussain, Sarah F. Pearce, Christopher A. Powell, Joanna Rorbach, Rebecca Lantaff, Sandra Blanco, Sascha Sauer, Urania Kotzaeridou, Georg F. Hoffmann, Yasin Memari, Anja Kolb-Kokocinski, Richard Durbin, Johannes A. Mayr, Michaela Frye, Holger Prokisch, Michal Minczuk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/95601b7fb2264bc4b7cdfae73ac97c8e
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spelling	oai:doaj.org-article:95601b7fb2264bc4b7cdfae73ac97c8e2021-12-02T16:56:46ZDeficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN310.1038/ncomms120392041-1723https://doaj.org/article/95601b7fb2264bc4b7cdfae73ac97c8e2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12039https://doaj.org/toc/2041-1723The post-transcriptional 5-methylcytosine (m5C) modification occurs in a wide range of nuclear-encoded RNAs. Here the authors identify the mitochondrial tRNA-Met as a target for the m5C methyltransferase NSun3—found mutated in a mitochondrial disease patient—and link mitochondrial tRNA modifications with energy metabolism.Lindsey Van HauteSabine DietmannLaura KremerShobbir HussainSarah F. PearceChristopher A. PowellJoanna RorbachRebecca LantaffSandra BlancoSascha SauerUrania KotzaeridouGeorg F. HoffmannYasin MemariAnja Kolb-KokocinskiRichard DurbinJohannes A. MayrMichaela FryeHolger ProkischMichal MinczukNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lindsey Van Haute Sabine Dietmann Laura Kremer Shobbir Hussain Sarah F. Pearce Christopher A. Powell Joanna Rorbach Rebecca Lantaff Sandra Blanco Sascha Sauer Urania Kotzaeridou Georg F. Hoffmann Yasin Memari Anja Kolb-Kokocinski Richard Durbin Johannes A. Mayr Michaela Frye Holger Prokisch Michal Minczuk Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
description	The post-transcriptional 5-methylcytosine (m5C) modification occurs in a wide range of nuclear-encoded RNAs. Here the authors identify the mitochondrial tRNA-Met as a target for the m5C methyltransferase NSun3—found mutated in a mitochondrial disease patient—and link mitochondrial tRNA modifications with energy metabolism.
format	article
author	Lindsey Van Haute Sabine Dietmann Laura Kremer Shobbir Hussain Sarah F. Pearce Christopher A. Powell Joanna Rorbach Rebecca Lantaff Sandra Blanco Sascha Sauer Urania Kotzaeridou Georg F. Hoffmann Yasin Memari Anja Kolb-Kokocinski Richard Durbin Johannes A. Mayr Michaela Frye Holger Prokisch Michal Minczuk
author_facet	Lindsey Van Haute Sabine Dietmann Laura Kremer Shobbir Hussain Sarah F. Pearce Christopher A. Powell Joanna Rorbach Rebecca Lantaff Sandra Blanco Sascha Sauer Urania Kotzaeridou Georg F. Hoffmann Yasin Memari Anja Kolb-Kokocinski Richard Durbin Johannes A. Mayr Michaela Frye Holger Prokisch Michal Minczuk
author_sort	Lindsey Van Haute
title	Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
title_short	Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
title_full	Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
title_fullStr	Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
title_full_unstemmed	Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
title_sort	deficient methylation and formylation of mt-trnamet wobble cytosine in a patient carrying mutations in nsun3
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/95601b7fb2264bc4b7cdfae73ac97c8e
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Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

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