Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center

Abstract [Au?1]: Objectives: The aim of this study was to describe the predictors and outcomes of infection with extended-spectrum beta-lactamase (ESBL)-producing bacteria in patients with an acute diabetic foot infection (DFI).Methods: The records of patients admitted with acute DFI to a large tert...

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Autores principales:	Michal Leibovitch, Avivit Cahn, Yechiel N. Gellman, Amir Haze, Shahar Peled, Sharon Amit, Ofer Elishoov, Karen Olshtain-Pops
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	ESBL-producing bacteria Diabetic foot ulcers Amputation Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/956341d14fd9486687ef87f05df9f6f3
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spelling	oai:doaj.org-article:956341d14fd9486687ef87f05df9f6f32021-11-16T04:09:12ZPredictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center1201-971210.1016/j.ijid.2021.10.016https://doaj.org/article/956341d14fd9486687ef87f05df9f6f32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008018https://doaj.org/toc/1201-9712Abstract [Au?1]: Objectives: The aim of this study was to describe the predictors and outcomes of infection with extended-spectrum beta-lactamase (ESBL)-producing bacteria in patients with an acute diabetic foot infection (DFI).Methods: The records of patients admitted with acute DFI to a large tertiary hospital during the years 2014–2018 were reviewed. Demographic, clinical, and laboratory data were collected, as well as outcomes regarding amputations and mortality. Only cultures obtained during the first 2 weeks following admission were considered.Results: Cultures were available for 493 patients; 121 (24.5%) included bacteria suspected of being ESBL producers. Patients infected with ESBL-producing bacteria were older, more likely to have peripheral vascular disease (PVD), and had higher SINBAD and Wagner scores upon admission. They were also more likely to have been hospitalized in the recent 6 months. Major amputations were more prevalent in patients with versus without an ESBL-producing bacterial infection (30.6% vs 19.4%; P = 0.010), yet overall amputations and mortality rates were similar.Conclusions: ESBL-producing bacteria are common pathogens in DFI, more prevalent in older patients with PVD, advanced ulcers, and recent hospitalization. They are associated with higher rates of major amputation. These considerations may support the choice of empirical antibiotic therapy in patients admitted with an acute DFI.Michal LeibovitchAvivit CahnYechiel N. GellmanAmir HazeShahar PeledSharon AmitOfer ElishoovKaren Olshtain-PopsElsevierarticleESBL-producing bacteriaDiabetic foot ulcersAmputationInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 318-324 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ESBL-producing bacteria Diabetic foot ulcers Amputation Infectious and parasitic diseases RC109-216
spellingShingle	ESBL-producing bacteria Diabetic foot ulcers Amputation Infectious and parasitic diseases RC109-216 Michal Leibovitch Avivit Cahn Yechiel N. Gellman Amir Haze Shahar Peled Sharon Amit Ofer Elishoov Karen Olshtain-Pops Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center
description	Abstract [Au?1]: Objectives: The aim of this study was to describe the predictors and outcomes of infection with extended-spectrum beta-lactamase (ESBL)-producing bacteria in patients with an acute diabetic foot infection (DFI).Methods: The records of patients admitted with acute DFI to a large tertiary hospital during the years 2014–2018 were reviewed. Demographic, clinical, and laboratory data were collected, as well as outcomes regarding amputations and mortality. Only cultures obtained during the first 2 weeks following admission were considered.Results: Cultures were available for 493 patients; 121 (24.5%) included bacteria suspected of being ESBL producers. Patients infected with ESBL-producing bacteria were older, more likely to have peripheral vascular disease (PVD), and had higher SINBAD and Wagner scores upon admission. They were also more likely to have been hospitalized in the recent 6 months. Major amputations were more prevalent in patients with versus without an ESBL-producing bacterial infection (30.6% vs 19.4%; P = 0.010), yet overall amputations and mortality rates were similar.Conclusions: ESBL-producing bacteria are common pathogens in DFI, more prevalent in older patients with PVD, advanced ulcers, and recent hospitalization. They are associated with higher rates of major amputation. These considerations may support the choice of empirical antibiotic therapy in patients admitted with an acute DFI.
format	article
author	Michal Leibovitch Avivit Cahn Yechiel N. Gellman Amir Haze Shahar Peled Sharon Amit Ofer Elishoov Karen Olshtain-Pops
author_facet	Michal Leibovitch Avivit Cahn Yechiel N. Gellman Amir Haze Shahar Peled Sharon Amit Ofer Elishoov Karen Olshtain-Pops
author_sort	Michal Leibovitch
title	Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center
title_short	Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center
title_full	Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center
title_fullStr	Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center
title_full_unstemmed	Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center
title_sort	predictors and outcomes of diabetic foot ulcer infection with esbl-producing bacteria in a large tertiary center
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/956341d14fd9486687ef87f05df9f6f3
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Predictors and outcomes of diabetic foot ulcer infection with ESBL-producing bacteria in a large tertiary center

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