Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells

Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.

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Autores principales:	Charandeep Singh, Vincent Tran, Leah McCollum, Youstina Bolok, Kristin Allan, Alex Yuan, George Hoppe, Henri Brunengraber, Jonathan E. Sears
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/956377e5821140ba84212046f44f2ab9
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spelling	oai:doaj.org-article:956377e5821140ba84212046f44f2ab92021-12-02T16:56:48ZHyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells10.1038/s41467-020-15066-62041-1723https://doaj.org/article/956377e5821140ba84212046f44f2ab92020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15066-6https://doaj.org/toc/2041-1723Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.Charandeep SinghVincent TranLeah McCollumYoustina BolokKristin AllanAlex YuanGeorge HoppeHenri BrunengraberJonathan E. SearsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charandeep Singh Vincent Tran Leah McCollum Youstina Bolok Kristin Allan Alex Yuan George Hoppe Henri Brunengraber Jonathan E. Sears Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
description	Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.
format	article
author	Charandeep Singh Vincent Tran Leah McCollum Youstina Bolok Kristin Allan Alex Yuan George Hoppe Henri Brunengraber Jonathan E. Sears
author_facet	Charandeep Singh Vincent Tran Leah McCollum Youstina Bolok Kristin Allan Alex Yuan George Hoppe Henri Brunengraber Jonathan E. Sears
author_sort	Charandeep Singh
title	Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
title_short	Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
title_full	Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
title_fullStr	Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
title_full_unstemmed	Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
title_sort	hyperoxia induces glutamine-fuelled anaplerosis in retinal müller cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/956377e5821140ba84212046f44f2ab9
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Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells

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