Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.
Guardado en:
Autores principales: | Charandeep Singh, Vincent Tran, Leah McCollum, Youstina Bolok, Kristin Allan, Alex Yuan, George Hoppe, Henri Brunengraber, Jonathan E. Sears |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/956377e5821140ba84212046f44f2ab9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
por: Man Tong, et al.
Publicado: (2021) -
Cytochrome P450-epoxygenated fatty acids inhibit Müller glial inflammation
por: Cayla D. Ontko, et al.
Publicado: (2021) -
Author Correction: Cytochrome P450-epoxygenated fatty acids inhibit Müller glial inflammation
por: Cayla D. Ontko, et al.
Publicado: (2021) -
Hypoxie and Hyperoxia
por: Zinner C, et al.
Publicado: (2019) -
Hypoxia & Hyperoxia
por: Böning D
Publicado: (2019)