Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells

Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.

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Autores principales: Charandeep Singh, Vincent Tran, Leah McCollum, Youstina Bolok, Kristin Allan, Alex Yuan, George Hoppe, Henri Brunengraber, Jonathan E. Sears
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/956377e5821140ba84212046f44f2ab9
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