Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge Lamellodysidea herbacea

Two known Polybrominated Diphenyl Ethers (PBDEs), 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)phenol (1d) and 3,4,5,6-tetrabromo-2-(2′,4′-dibromophenoxy)phenol (2b), were isolated from the Indonesian marine sponge Lamellodysidea herbacea. The struc...

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Autores principales:	Muhammad R. Faisal, Matthias Y. Kellermann, Sven Rohde, Masteria Y. Putra, Tutik Murniasih, Chandra Risdian, Kathrin I. Mohr, Joachim Wink, Dimas F. Praditya, Eike Steinmann, Matthias Köck, Peter J. Schupp
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	demospongiae chemical defense palatability antifungal inhibitory PBDEs Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/95640022e12a4bea9129ae078163352c
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spelling	oai:doaj.org-article:95640022e12a4bea9129ae078163352c2021-11-25T18:12:48ZEcological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>10.3390/md191106111660-3397https://doaj.org/article/95640022e12a4bea9129ae078163352c2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/611https://doaj.org/toc/1660-3397Two known Polybrominated Diphenyl Ethers (PBDEs), 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)phenol (<b>1d</b>) and 3,4,5,6-tetrabromo-2-(2′,4′-dibromophenoxy)phenol (<b>2b</b>), were isolated from the Indonesian marine sponge <i>Lamellodysidea herbacea</i>. The structure was confirmed using <sup>13</sup>C chemical shift average deviation and was compared to the predicted structures and recorded chemical shifts in previous studies. We found a wide range of bioactivities from the organic crude extract, such as (1) a strong deterrence against the generalist pufferfish <i>Canthigaster solandri</i>, (2) potent inhibition against environmental and human pathogenic bacterial and fungal strains, and (3) the inhibition of the Hepatitis C Virus (HCV). The addition of a bromine atom into the A-ring of compound <b>2b</b> resulted in higher fish feeding deterrence compared to compound <b>1d</b>. On the contrary, compound <b>2b</b> showed only more potent inhibition against the Gram-negative bacteria <i>Rhodotorula glutinis</i> (MIC 2.1 μg/mL), while compound <b>1d</b> showed more powerful inhibition against the other human pathogenic bacteria and fungi. The first report of a chemical defense by compounds <b>1d</b> and <b>2b</b> against fish feeding and environmental relevant bacteria, especially pathogenic bacteria, might be one reason for the widespread occurrence of the shallow water sponge <i>Lamellodysidea herbacea</i> in Indonesia and the Indo-Pacific.Muhammad R. FaisalMatthias Y. KellermannSven RohdeMasteria Y. PutraTutik MurniasihChandra RisdianKathrin I. MohrJoachim WinkDimas F. PradityaEike SteinmannMatthias KöckPeter J. SchuppMDPI AGarticledemospongiaechemical defensepalatabilityantifungalinhibitoryPBDEsBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 611, p 611 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	demospongiae chemical defense palatability antifungal inhibitory PBDEs Biology (General) QH301-705.5
spellingShingle	demospongiae chemical defense palatability antifungal inhibitory PBDEs Biology (General) QH301-705.5 Muhammad R. Faisal Matthias Y. Kellermann Sven Rohde Masteria Y. Putra Tutik Murniasih Chandra Risdian Kathrin I. Mohr Joachim Wink Dimas F. Praditya Eike Steinmann Matthias Köck Peter J. Schupp Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>
description	Two known Polybrominated Diphenyl Ethers (PBDEs), 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)phenol (<b>1d</b>) and 3,4,5,6-tetrabromo-2-(2′,4′-dibromophenoxy)phenol (<b>2b</b>), were isolated from the Indonesian marine sponge <i>Lamellodysidea herbacea</i>. The structure was confirmed using <sup>13</sup>C chemical shift average deviation and was compared to the predicted structures and recorded chemical shifts in previous studies. We found a wide range of bioactivities from the organic crude extract, such as (1) a strong deterrence against the generalist pufferfish <i>Canthigaster solandri</i>, (2) potent inhibition against environmental and human pathogenic bacterial and fungal strains, and (3) the inhibition of the Hepatitis C Virus (HCV). The addition of a bromine atom into the A-ring of compound <b>2b</b> resulted in higher fish feeding deterrence compared to compound <b>1d</b>. On the contrary, compound <b>2b</b> showed only more potent inhibition against the Gram-negative bacteria <i>Rhodotorula glutinis</i> (MIC 2.1 μg/mL), while compound <b>1d</b> showed more powerful inhibition against the other human pathogenic bacteria and fungi. The first report of a chemical defense by compounds <b>1d</b> and <b>2b</b> against fish feeding and environmental relevant bacteria, especially pathogenic bacteria, might be one reason for the widespread occurrence of the shallow water sponge <i>Lamellodysidea herbacea</i> in Indonesia and the Indo-Pacific.
format	article
author	Muhammad R. Faisal Matthias Y. Kellermann Sven Rohde Masteria Y. Putra Tutik Murniasih Chandra Risdian Kathrin I. Mohr Joachim Wink Dimas F. Praditya Eike Steinmann Matthias Köck Peter J. Schupp
author_facet	Muhammad R. Faisal Matthias Y. Kellermann Sven Rohde Masteria Y. Putra Tutik Murniasih Chandra Risdian Kathrin I. Mohr Joachim Wink Dimas F. Praditya Eike Steinmann Matthias Köck Peter J. Schupp
author_sort	Muhammad R. Faisal
title	Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>
title_short	Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>
title_full	Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>
title_fullStr	Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>
title_full_unstemmed	Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>
title_sort	ecological and pharmacological activities of polybrominated diphenyl ethers (pbdes) from the indonesian marine sponge <i>lamellodysidea herbacea</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/95640022e12a4bea9129ae078163352c
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Ecological and Pharmacological Activities of Polybrominated Diphenyl Ethers (PBDEs) from the Indonesian Marine Sponge <i>Lamellodysidea herbacea</i>

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