CD4+ effector T cells accelerate Alzheimer’s disease in mice

CD4+ effector T cells accelerate Alzheimer’s disease in mice

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in kind facilitates tau aggregation and neurodegeneration. Neuroinflammation is accepted as a key disease driver caused...

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Main Authors: Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Format: article
Language:EN
Published: BMC 2021
Subjects:
Alzheimer’s disease (AD)
Amyloid beta (Aβ)
T cell
Effector T cell (Teff)
Regulatory T cell (Treg)
APP/PS1 transgenic mice
Neurology. Diseases of the nervous system
RC346-429
Online Access:https://doaj.org/article/9566142d7b6b497fa6e8c5d16550ee05
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https://doaj.org/article/9566142d7b6b497fa6e8c5d16550ee05

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