Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

LDL receptor-related protein 1 (LRP1) is an endocytic receptor involved in cell signalling and energy homeostasis. Here Maoet al. demonstrate that endothelial Lrp1 modulates lipid and glucose metabolism by binding the nuclear receptor Pparγ and promoting its transcriptional activity.

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Autores principales:	Hua Mao, Pamela Lockyer, Luge Li, Christie M. Ballantyne, Cam Patterson, Liang Xie, Xinchun Pi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9568598d8eac4446926e96a6f3554058
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spelling	oai:doaj.org-article:9568598d8eac4446926e96a6f35540582021-12-02T14:40:24ZEndothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ10.1038/ncomms149602041-1723https://doaj.org/article/9568598d8eac4446926e96a6f35540582017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14960https://doaj.org/toc/2041-1723LDL receptor-related protein 1 (LRP1) is an endocytic receptor involved in cell signalling and energy homeostasis. Here Maoet al. demonstrate that endothelial Lrp1 modulates lipid and glucose metabolism by binding the nuclear receptor Pparγ and promoting its transcriptional activity.Hua MaoPamela LockyerLuge LiChristie M. BallantyneCam PattersonLiang XieXinchun PiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hua Mao Pamela Lockyer Luge Li Christie M. Ballantyne Cam Patterson Liang Xie Xinchun Pi Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
description	LDL receptor-related protein 1 (LRP1) is an endocytic receptor involved in cell signalling and energy homeostasis. Here Maoet al. demonstrate that endothelial Lrp1 modulates lipid and glucose metabolism by binding the nuclear receptor Pparγ and promoting its transcriptional activity.
format	article
author	Hua Mao Pamela Lockyer Luge Li Christie M. Ballantyne Cam Patterson Liang Xie Xinchun Pi
author_facet	Hua Mao Pamela Lockyer Luge Li Christie M. Ballantyne Cam Patterson Liang Xie Xinchun Pi
author_sort	Hua Mao
title	Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
title_short	Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
title_full	Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
title_fullStr	Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
title_full_unstemmed	Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ
title_sort	endothelial lrp1 regulates metabolic responses by acting as a co-activator of pparγ
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9568598d8eac4446926e96a6f3554058
work_keys_str_mv	AT huamao endotheliallrp1regulatesmetabolicresponsesbyactingasacoactivatorofpparg AT pamelalockyer endotheliallrp1regulatesmetabolicresponsesbyactingasacoactivatorofpparg AT lugeli endotheliallrp1regulatesmetabolicresponsesbyactingasacoactivatorofpparg AT christiemballantyne endotheliallrp1regulatesmetabolicresponsesbyactingasacoactivatorofpparg AT campatterson endotheliallrp1regulatesmetabolicresponsesbyactingasacoactivatorofpparg AT liangxie endotheliallrp1regulatesmetabolicresponsesbyactingasacoactivatorofpparg AT xinchunpi endotheliallrp1regulatesmetabolicresponsesbyactingasacoactivatorofpparg
_version_	1718390311069155328

Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

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