Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus

Lupus pathogenesis is associated with high type 1 interferon stimulated gene (ISG) expression. Here, the authors correlate ISG expression in CD8+ T cells from lupus nephritis patients with abnormal mitochondrial function, implicating increased NAD consumption and reduced cell viability in the pathog...

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Autores principales:	Norzawani Buang, Lunnathaya Tapeng, Victor Gray, Alessandro Sardini, Chad Whilding, Liz Lightstone, Thomas D. Cairns, Matthew C. Pickering, Jacques Behmoaras, Guang Sheng Ling, Marina Botto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/956b2c52bede4e939180a254c3701f31
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spelling	oai:doaj.org-article:956b2c52bede4e939180a254c3701f312021-12-02T14:23:03ZType I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus10.1038/s41467-021-22312-y2041-1723https://doaj.org/article/956b2c52bede4e939180a254c3701f312021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22312-yhttps://doaj.org/toc/2041-1723Lupus pathogenesis is associated with high type 1 interferon stimulated gene (ISG) expression. Here, the authors correlate ISG expression in CD8+ T cells from lupus nephritis patients with abnormal mitochondrial function, implicating increased NAD consumption and reduced cell viability in the pathogenesis.Norzawani BuangLunnathaya TapengVictor GrayAlessandro SardiniChad WhildingLiz LightstoneThomas D. CairnsMatthew C. PickeringJacques BehmoarasGuang Sheng LingMarina BottoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Norzawani Buang Lunnathaya Tapeng Victor Gray Alessandro Sardini Chad Whilding Liz Lightstone Thomas D. Cairns Matthew C. Pickering Jacques Behmoaras Guang Sheng Ling Marina Botto Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
description	Lupus pathogenesis is associated with high type 1 interferon stimulated gene (ISG) expression. Here, the authors correlate ISG expression in CD8+ T cells from lupus nephritis patients with abnormal mitochondrial function, implicating increased NAD consumption and reduced cell viability in the pathogenesis.
format	article
author	Norzawani Buang Lunnathaya Tapeng Victor Gray Alessandro Sardini Chad Whilding Liz Lightstone Thomas D. Cairns Matthew C. Pickering Jacques Behmoaras Guang Sheng Ling Marina Botto
author_facet	Norzawani Buang Lunnathaya Tapeng Victor Gray Alessandro Sardini Chad Whilding Liz Lightstone Thomas D. Cairns Matthew C. Pickering Jacques Behmoaras Guang Sheng Ling Marina Botto
author_sort	Norzawani Buang
title	Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
title_short	Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
title_full	Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
title_fullStr	Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
title_full_unstemmed	Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
title_sort	type i interferons affect the metabolic fitness of cd8+ t cells from patients with systemic lupus erythematosus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/956b2c52bede4e939180a254c3701f31
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Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus

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