Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly

Renee Hartog,1,* Davide Bolignano,1,2,* Eric Sijbrands,1 Giacomo Pucci,3,4 Francesco Mattace-Raso1 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Institute of Clinical Physiology, Italian National Council of Research, Reggio Calabria, Italy; 3Depar...

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Autores principales:	Hartog R, Bolignano D, Sijbrands E, Pucci G, Mattace-Raso F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	vascular aging isometric stress blood pressure pulse wave velocity Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/956c576d49e544da9455d937de18e2f1
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spelling	oai:doaj.org-article:956c576d49e544da9455d937de18e2f12021-12-02T04:35:50ZShort-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly1178-1998https://doaj.org/article/956c576d49e544da9455d937de18e2f12018-04-01T00:00:00Zhttps://www.dovepress.com/short-term-vascular-hemodynamic-responses-to-isometric-exercise-in-you-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Renee Hartog,1,* Davide Bolignano,1,2,* Eric Sijbrands,1 Giacomo Pucci,3,4 Francesco Mattace-Raso1 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Institute of Clinical Physiology, Italian National Council of Research, Reggio Calabria, Italy; 3Department of Medicine, University of Perugia, Perugia, Italy; 4Unit of Internal Medicine, Terni University Hospital, Terni, Italy *These authors contributed equally to this work Background: Vascular aging is known to induce progressive stiffening of the large elastic arteries, altering vascular hemodynamics under both rest and stress conditions. In this study, we aimed to investigate changes in vascular hemodynamics in response to isometric handgrip exercise across ages.Participants and methods: We included 62 participants, who were divided into three age categories: 20–40 (n=22), 41–60 (n=20), and 61–80 (n=20) years. Vascular hemodynamics were measured using the Mobil-o-Graph® based on the pulsatile pressure changes in the brachial artery. One-way ANOVA test was performed to analyze the changes induced by isometric handgrip exercise.Results: After isometric handgrip exercise, aortic pulse wave velocity (PWV) increased by 0.10 m/s in the youngest, 0.06 m/s in the middle-age, and 0.02 m/s in the oldest age category. Changes in PWV strongly correlated with those in central systolic blood pressure (cSBP) (r=0.878, P<0.01). After isometric exercise, the mean change of systolic blood pressure (SBP) was -1.9% in the youngest, 0.6% in the middle-aged, and 8.2% in the oldest subjects. Increasing handgrip strength was associated with an increase in SBP and cSBP (1.08 and 1.37 mmHg per 1 kg increase in handgrip strength, respectively, P=0.01). Finally, PWV was significantly associated with increasing handgrip strength with an increase of 0.05 m/s per 1 kg higher handgrip strength (P=0.01).Conclusion: This study found increased blood pressure levels after isometric challenge and a strong association between handgrip strength and change in blood pressure levels and aortic stiffness in elderly subjects. Keywords: vascular aging, isometric stress, blood pressure, pulse wave velocity Hartog RBolignano DSijbrands EPucci GMattace-Raso FDove Medical Pressarticlevascular agingisometric stressblood pressurepulse wave velocityGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 509-514 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular aging isometric stress blood pressure pulse wave velocity Geriatrics RC952-954.6
spellingShingle	vascular aging isometric stress blood pressure pulse wave velocity Geriatrics RC952-954.6 Hartog R Bolignano D Sijbrands E Pucci G Mattace-Raso F Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
description	Renee Hartog,1,* Davide Bolignano,1,2,* Eric Sijbrands,1 Giacomo Pucci,3,4 Francesco Mattace-Raso1 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Institute of Clinical Physiology, Italian National Council of Research, Reggio Calabria, Italy; 3Department of Medicine, University of Perugia, Perugia, Italy; 4Unit of Internal Medicine, Terni University Hospital, Terni, Italy *These authors contributed equally to this work Background: Vascular aging is known to induce progressive stiffening of the large elastic arteries, altering vascular hemodynamics under both rest and stress conditions. In this study, we aimed to investigate changes in vascular hemodynamics in response to isometric handgrip exercise across ages.Participants and methods: We included 62 participants, who were divided into three age categories: 20–40 (n=22), 41–60 (n=20), and 61–80 (n=20) years. Vascular hemodynamics were measured using the Mobil-o-Graph® based on the pulsatile pressure changes in the brachial artery. One-way ANOVA test was performed to analyze the changes induced by isometric handgrip exercise.Results: After isometric handgrip exercise, aortic pulse wave velocity (PWV) increased by 0.10 m/s in the youngest, 0.06 m/s in the middle-age, and 0.02 m/s in the oldest age category. Changes in PWV strongly correlated with those in central systolic blood pressure (cSBP) (r=0.878, P<0.01). After isometric exercise, the mean change of systolic blood pressure (SBP) was -1.9% in the youngest, 0.6% in the middle-aged, and 8.2% in the oldest subjects. Increasing handgrip strength was associated with an increase in SBP and cSBP (1.08 and 1.37 mmHg per 1 kg increase in handgrip strength, respectively, P=0.01). Finally, PWV was significantly associated with increasing handgrip strength with an increase of 0.05 m/s per 1 kg higher handgrip strength (P=0.01).Conclusion: This study found increased blood pressure levels after isometric challenge and a strong association between handgrip strength and change in blood pressure levels and aortic stiffness in elderly subjects. Keywords: vascular aging, isometric stress, blood pressure, pulse wave velocity
format	article
author	Hartog R Bolignano D Sijbrands E Pucci G Mattace-Raso F
author_facet	Hartog R Bolignano D Sijbrands E Pucci G Mattace-Raso F
author_sort	Hartog R
title	Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
title_short	Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
title_full	Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
title_fullStr	Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
title_full_unstemmed	Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
title_sort	short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/956c576d49e544da9455d937de18e2f1
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Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly

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