Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Tumour-specific T cells can be expandedin vitroand adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell mem...

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Autores principales:	Taisuke Kondo, Rimpei Morita, Yuumi Okuzono, Hiroko Nakatsukasa, Takashi Sekiya, Shunsuke Chikuma, Takashi Shichita, Mitsuhiro Kanamori, Masato Kubo, Keiko Koga, Takahiro Miyazaki, Yoshiaki Kassai, Akihiko Yoshimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/956f24e4dd8a4d5881a8d99fc61d6ef7
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spelling	oai:doaj.org-article:956f24e4dd8a4d5881a8d99fc61d6ef72021-12-02T14:42:36ZNotch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy10.1038/ncomms153382041-1723https://doaj.org/article/956f24e4dd8a4d5881a8d99fc61d6ef72017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15338https://doaj.org/toc/2041-1723Tumour-specific T cells can be expandedin vitroand adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell memory T cell population that can fight tumours in mice.Taisuke KondoRimpei MoritaYuumi OkuzonoHiroko NakatsukasaTakashi SekiyaShunsuke ChikumaTakashi ShichitaMitsuhiro KanamoriMasato KuboKeiko KogaTakahiro MiyazakiYoshiaki KassaiAkihiko YoshimuraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taisuke Kondo Rimpei Morita Yuumi Okuzono Hiroko Nakatsukasa Takashi Sekiya Shunsuke Chikuma Takashi Shichita Mitsuhiro Kanamori Masato Kubo Keiko Koga Takahiro Miyazaki Yoshiaki Kassai Akihiko Yoshimura Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
description	Tumour-specific T cells can be expandedin vitroand adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell memory T cell population that can fight tumours in mice.
format	article
author	Taisuke Kondo Rimpei Morita Yuumi Okuzono Hiroko Nakatsukasa Takashi Sekiya Shunsuke Chikuma Takashi Shichita Mitsuhiro Kanamori Masato Kubo Keiko Koga Takahiro Miyazaki Yoshiaki Kassai Akihiko Yoshimura
author_facet	Taisuke Kondo Rimpei Morita Yuumi Okuzono Hiroko Nakatsukasa Takashi Sekiya Shunsuke Chikuma Takashi Shichita Mitsuhiro Kanamori Masato Kubo Keiko Koga Takahiro Miyazaki Yoshiaki Kassai Akihiko Yoshimura
author_sort	Taisuke Kondo
title	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_short	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_full	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_fullStr	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_full_unstemmed	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_sort	notch-mediated conversion of activated t cells into stem cell memory-like t cells for adoptive immunotherapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/956f24e4dd8a4d5881a8d99fc61d6ef7
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Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

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