THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C

Abstract. Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Liver damage in chronic viral hepatitis C is caused by both direct cytopathic viral effects, and indirect immune-mediated mechanisms. The cytokines locally produced in the liver...

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Autor principal:	L. Ph. Skljar
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic viral hepatitis c cytokines fibrosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/957037b3cd1a44a59fae964c7c09853a
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spelling	oai:doaj.org-article:957037b3cd1a44a59fae964c7c09853a2021-11-18T08:03:41ZTHE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C1563-06252313-741X10.15789/1563-0625-2006-1-81-86https://doaj.org/article/957037b3cd1a44a59fae964c7c09853a2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/441https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Liver damage in chronic viral hepatitis C is caused by both direct cytopathic viral effects, and indirect immune-mediated mechanisms. The cytokines locally produced in the liver, as well as those circulating in the blood circulation, play an important role in the control of viral replication and sufficiently contribute to hepatocellular damage. The goal of present study was to investigate the contents of some cytokines in blood serum and their local levels, being in interrelation with indices of necrotic inflammatory changes in the liver tissue. Correlations established between systemic and local contents of studied cytokines, and morphological indices indicate that, among immunological tests checked, the contents of IL-4, IL-10, IL-12p70, and TNFα in blood serum and supernatants of liver biopsies were of the greatest significance for determining the stage of fibrosis. Quantitative assays of abovementioned cytokines in blood serum represent, therefore, an alternative approach in order to perform noninvasive screening of liver fibrosis.L. Ph. SkljarSPb RAACIarticlechronic viral hepatitis ccytokinesfibrosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 1, Pp 81-86 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic viral hepatitis c cytokines fibrosis Immunologic diseases. Allergy RC581-607
spellingShingle	chronic viral hepatitis c cytokines fibrosis Immunologic diseases. Allergy RC581-607 L. Ph. Skljar THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C
description	Abstract. Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Liver damage in chronic viral hepatitis C is caused by both direct cytopathic viral effects, and indirect immune-mediated mechanisms. The cytokines locally produced in the liver, as well as those circulating in the blood circulation, play an important role in the control of viral replication and sufficiently contribute to hepatocellular damage. The goal of present study was to investigate the contents of some cytokines in blood serum and their local levels, being in interrelation with indices of necrotic inflammatory changes in the liver tissue. Correlations established between systemic and local contents of studied cytokines, and morphological indices indicate that, among immunological tests checked, the contents of IL-4, IL-10, IL-12p70, and TNFα in blood serum and supernatants of liver biopsies were of the greatest significance for determining the stage of fibrosis. Quantitative assays of abovementioned cytokines in blood serum represent, therefore, an alternative approach in order to perform noninvasive screening of liver fibrosis.
format	article
author	L. Ph. Skljar
author_facet	L. Ph. Skljar
author_sort	L. Ph. Skljar
title	THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C
title_short	THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C
title_full	THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C
title_fullStr	THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C
title_full_unstemmed	THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C
title_sort	role of cytokine network in hepatocellular damage caused by сhronic hepatitis c
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/957037b3cd1a44a59fae964c7c09853a
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THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C

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